Enabling remote medical physics services for medical accelerator quality assurance through a novel, table-top imaging device

通过新颖的桌面成像设备实现远程医学物理服务,以保证医疗加速器的质量

基本信息

  • 批准号:
    10773360
  • 负责人:
  • 金额:
    $ 5.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-01 至 2023-06-30
  • 项目状态:
    已结题

项目摘要

Executive Summary Radiation Therapy is an effective component of the treatment strategy for patients suffering from cancer. Advanced techniques such as intensity modulated radiation therapy (IMRT), image-guided RT (IGRT), stereotactic body RT (SBRT) and stereotactic radiosurgery (SRS) improve outcomes and are delivered using medical linear accelerators (i.e., ‘linacs”). SBRT is especially appealing given that the precise treatments are delivered in 1-5 daily treatment fractions, as opposed to the 20-40 fractions required for conventional techniques. Providing SBRT in rural settings can improve access by administering these precise, abbreviated treatments to patients who have difficulty traveling to large, regional medical centers. Further, adoption of automated techniques for quality control and enhanced tele-dosimetry can support peer review, improve quality, reduce dependence on (local) expertise and reduce operating costs. The quality assurance (QA) that medical physicists provide is critical for safe treatments, yet there is a shortage of qualified medical physicists (QMPs), both in the US and globally. At the same time, more centers are introducing modern techniques that are more precise but intrinsically have more risk, due the high doses and geometric precision required. There is widespread noncompliance with industry standard QA protocols in the US and internationally. Existing QA devices have not evolved sufficiently to provide the precision, versatility and efficiency that is needed for high precision RT. Given these exacerbated safety risks, the market needs a paradigm shift in how QA is performed in modern RT. Wild Dog Physics (WDP) proposes to design and test a new-generation QA device that addresses these unmet medical needs. When complete, it will be more precise, efficient, and comprehensive than any QA solution currently on the market. The proposed project seeks to develop a clinical prototype to be tested in the Radiation Therapy clinic at the University of Kentucky, as well as regional partner organizations located in rural, underserved areas. The prototype will be developed using the following milestones: Design and build i) a novel, a small-form-factor optical tunnel (SFFOT), ii) a laminated side wall with a scintillating phosphor screen and ‘switchable film’ outer layer to facilitate ambient light rejection and iii), a hybrid beam quality / compact CT phantom. The project will culminate with the construction of an integrated prototype that will be tested for technical and clinical performance. Towards this end, the specific aims of this project are: Specific Aim 1: Build and test the 3 primary subcomponents of an integrated device; a) a SFFOT that can collect an image(s) of the entire useful interior surface, transmit the image(s) to an electronic camera sensor through a small form-factor (< 5 cm diameter) passive optical chain; b) a laminated side wall consisting of an outer, electronically polarizing optical layer, and an inner radio-luminescent layer, and c) a hybrid ‘dose phantom’ to be integrated onto one side of the device which will serve as a tissue-equivalent phantom so that beam quality metrics can be monitored and to host CT image quality test objects. Specific Aim 2: Construct and test a clinical prototype; The system’s ability to monitor machine performance in a clinical setting will be validated. Sensitivity to detecting changes in relative and absolute radiation output, as well as field edge positioning will be measured, with success criteria defined as 0.5% and 0.5 mm. Data acquisition time for monthly QA tests will be measured and success defined as less than 30 minutes. The consolidation of multiple device functions combined with the ease of use and measurement precision enable a paradigm shift in how medical physics services and quality assurance are rendered. Sparse but efficient daily QA protocols will be replaced with comprehensive data collection and automated analysis, at no additional cost in time or staffing. High precision radiation treatments can be safely brought to rural and underserved areas, with safety, efficiency and precision improved in any center using the innovation. To date, we have established the feasibility of constructing a single device that can acquire comprehensive QA metrics in less than 60 minutes. Presently, all subsystems have been tested and found to perform as required. A three-dimensional prototype has been built and is being validated by our clinical partner at the UK Radiation Medicine department. WDP is in the process of seeking SBIR Phase 2 funding to further develop the technology to the point of commercialization.
执行摘要 放射治疗是治疗策略的有效组成部分, 癌先进技术,如调强放射治疗(IMRT)、图像引导RT(IGRT), 立体定向体部RT(SBRT)和立体定向放射外科(SRS)可改善结局, 医用线性加速器(即,“直线加速器”)。SBRT特别有吸引力,因为精确的治疗方法 在1-5个每日治疗部分中递送,而不是常规治疗所需的20-40个部分。 技术.在农村地区提供SBRT可以通过管理这些精确的,简短的 为难以前往大型区域医疗中心的患者提供治疗。此外,通过 质量控制和增强的远程剂量测定的自动化技术可以支持同行评审, 质量,减少对(当地)专业知识的依赖,降低运营成本。 医学物理学家提供的质量保证(QA)对于安全治疗至关重要,但 在美国和全球范围内,合格的医学物理学家(QMP)短缺。同时,更多的中心 正在引入更精确的现代技术,但由于高剂量, 和所需的几何精度。存在广泛的不符合行业标准QA协议的情况, 美国和国际。现有的QA设备还没有充分发展,以提供精确性、多功能性 鉴于这些加剧的安全风险,市场需要一个 在现代RT中如何执行QA的范式转变。 野狗物理(WDP)提出设计和测试新一代QA设备,解决这些问题 未满足的医疗需求。完成后,它将比任何QA更精确,更高效,更全面 目前市场上的解决方案。拟议项目旨在开发一种临床原型, 肯塔基州大学的放射治疗诊所,以及位于 农村,服务不足的地区。原型将使用以下里程碑开发:设计和建造i) 一种新颖的小形状因子光学隧道(SFFOT),ii)具有磷光体的层压侧壁, 屏幕和“可切换膜”外层,以促进环境光抑制,以及iii)混合光束质量/ 紧凑型CT体模。该项目将最终建设一个综合原型, 测试技术和临床性能。 为此,该项目的具体目标是: 具体目标1:构建和测试集成设备的3个主要子组件; a)SFFOT, 收集整个有用内表面的图像,将图像传输到电子照相机传感器 B)层压侧壁,所述层压侧壁由 外部电子偏振光学层和内部辐射发光层,以及c)混合“剂量”, 体模”将集成到设备的一侧,该设备将用作组织等效体模,以便 可以监视射束质量度量,并托管CT图像质量测试对象。 具体目标2:构建并测试临床原型;系统在以下条件下监测机器性能的能力 将验证临床环境。检测相对和绝对辐射输出变化的灵敏度,如 将测量射野边缘定位,成功标准定义为0.5%和0.5 mm。数据 将测量每月QA测试的采集时间,成功定义为少于30分钟。 多种设备功能的整合,以及易用性和测量 精确性使医疗物理服务和质量保证的模式发生了转变。稀疏 但高效的日常QA协议将被全面的数据收集和自动化分析所取代, 没有额外的时间和人力成本。高精度放射治疗可以安全地带到农村, 在服务水平低下的地区,任何使用该创新的中心都能提高安全性、效率和精度。 到目前为止,我们已经建立了构建一个单一设备的可行性, 在不到60分钟的时间内完成全面的QA指标。目前,所有子系统都已经过测试,发现 按要求执行。一个三维原型已经建成,并正在验证我们的临床 英国放射医学部的合伙人。WDP正在寻求SBIR第2阶段资金, 进一步将技术发展到商业化的程度。

项目成果

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Janelle Arlene Molloy其他文献

Janelle Arlene Molloy的其他文献

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{{ truncateString('Janelle Arlene Molloy', 18)}}的其他基金

Enabling remote medical physics services for medical accelerator quality assurance through a novel, table-top imaging device
通过新颖的桌面成像设备实现远程医学物理服务,以保证医疗加速器的质量
  • 批准号:
    10256613
  • 财政年份:
    2021
  • 资助金额:
    $ 5.5万
  • 项目类别:

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