Biostatistics and Bioinformatics Shared Resource

生物统计学和生物信息学共享资源

• 批准号: 10784809
• 负责人: Jennifer Cullen
• 金额: $ 35.3万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10784809
• 关键词: Adopted; Bioinformatics; Bioinformatics Shared Resource; Biometry; Cancer Center Support Grant; Clinic; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Collaborations; Comprehensive Cancer Center; Computational Biology; Computer software; Data; Data Analyses; Data Science; Data Set; Database Management Systems; Databases; Development; Doctor of Philosophy; Education; Ensure; Environment; Epidemiology; Experimental Designs; Formulation; Funding; Future; Grant; Hour; Human Resources; Informatics; Institution; Malignant Neoplasms; Manuscripts; Medicine; Mission; Modeling; Monitor; Peer Review; Pilot Projects; Process; Productivity; Protocols documentation; Quality Control; Reporting; Research; Research Personnel; Research Project Grants; Resources; Safety; Sample Size; Science; Secure; Services; Statistical Computing; Statistical Data Interpretation; Translational Research; United States National Institutes of Health; Universities; Work; Writing; bioinformatics tool; data quality; data warehouse; design; meetings; member; mid-career faculty; novel; operation; professor; programs; protocol development; research study; response; success

BIOSTATISTICS AND BIOINFORMATICS SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Shared Resource (Biostats SR) is an essential asset to Case Comprehensive Cancer Center (Case CCC) members' research, illustrated by the breadth of scientific program involvement and reflected in the large number of investigators who use this SR. Last year alone over 140 investigators, 53% of whom were Case CCC members, from all 7 of the Center's Programs, used the SR on over 300 projects, for a combined 6,500 hours. The primary focus of the Biostats SR is to provide statistical support for proposal/clinical protocol development, pilot studies, or other NIH-funded peer-reviewed studies. In addition, using a standard chargeback model and collaborative grant effort model, this SR provides data analysis services including big and dense omic datasets. The Biostats SR also leverages institutional resources from the Institute for Computational Biology (ICB) to provide and strengthen informatics support. The Biostats SR brings together expertise and intellectual resources in biostatistics, bioinformatics, informatics, clinical trials, epidemiology, and statistical computing. The Biostats SR provides data analysis services using standard chargeback and collaborative grant effort models. Biostats SR biostatisticians serve on the Protocol Review and Monitoring Committee (PRMC), assisting with review of new studies and monitoring of ongoing studies. Specific aims of the Biostatistics & Bioinformatics Shared Resource are to: 1) Provide biostatistical, bioinformatics, and research informatics support to Case CCC members for design, planning, conduct, analysis, and reporting of research studies. 2) Ensure that Case CCC studies are designed, conducted, and monitored properly by reviewing protocols and proposals, and contribute to quality control and data and safety monitoring of ongoing clinical studies. 3) Provide and coordinate informatics support by using the OnCore clinical trials management database and other secure research databases, and serve as a concierge for translational informatics in the Case CCC. At last review, the Biostats SR was rated “Outstanding Merit”. Throughout the current funding cycle (2012-2016), the Biostats SR provided services to 298 registered users, 134 (45%) of whom are Case CCC members, representing all 7 of the Case CCC programs. The value-added services (formulation of research questions and experimental design, power and sample size calculations, data quality assessment and control, statistical analysis, results interpretation, as well as proposal/manuscript writing and support) provided by the Biostats SR is demonstrated by the successful contribution of Biostats SR personnel to the Center’s research productivity. Initial collaborations supported by the Center often lead to successful new funding via collaborative research grants on which Biostats SR personnel serve as co-investigators. Biostats SR services are essential in enhancing the quality of science in the Center.

生物统计学和生物信息学共享资源 项目总结/摘要 生物统计学和生物信息学共享资源（Biostats SR）是Case的重要资产 综合癌症中心（Case CCC）成员的研究，以科学计划的广度为例 参与，并反映在大量的调查人员谁使用这一SR。仅去年一年就超过140 来自该中心所有7个项目的调查人员，其中53%是案例CCC成员，使用SR对 超过300个项目，总计6,500小时。Biostats SR的主要重点是提供统计 支持提案/临床方案开发、试点研究或其他NIH资助的同行评审研究。在 此外，使用标准的按存储容量使用计费模型和协作资助工作模型，该SR提供数据分析 服务包括大而密集的omic数据集。Biostats SR还利用来自 计算生物学研究所（ICB）提供和加强信息学支持。Biostats SR带来了 将生物统计学、生物信息学、信息学、临床试验、 流行病学和统计计算。Biostats SR提供使用标准的数据分析服务 退款和协作赠款工作模式。Biostats SR生物统计学家负责方案审查， 监查委员会（PRMC），协助审查新研究和监查正在进行的研究。 生物统计学和生物信息学共享资源的具体目标是： 1)为Case CCC成员提供生物统计、生物信息学和研究信息学支持，以进行设计， 规划、开展、分析和报告研究。 2)通过审查方案，确保病例CCC研究的设计、实施和监测正确 和建议，并有助于正在进行的临床研究的质量控制、数据和安全监测。 3)通过使用OnCore临床试验管理数据库提供和协调信息学支持 和其他安全的研究数据库，并作为一个礼宾翻译信息学的情况下 CCC. 在上次审查中，Biostats SR被评为“杰出优点”。在本供资周期（2012-2016年）， Biostats SR为298名注册用户提供了服务，其中134名（45%）是Case CCC成员， 代表所有7个案例CCC计划。 增值服务（研究问题和实验设计的制定、把握度和样本量 计算、数据质量评估和控制、统计分析、结果解释以及 建议/手稿写作和支持）提供的Biostats SR是证明了成功的 Biostats SR人员对中心研究生产力的贡献。支持的初步合作 该中心经常通过合作研究赠款成功地获得新的资金，Biostats SR人员 担任共同调查员。Biostats SR服务对于提高中心的科学质量至关重要。