PATHOGENICITY OF A NEWLY IDENTIFIED HUMAN PARVOVIRUS

新鉴定的人类细小病毒的致病性

• 批准号: 7562240
• 负责人: ERIC L DELWART
• 金额: $ 5.74万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562240
• 关键词: Adolescent; Adult; Animals; CD8-Positive T-Lymphocytes; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Human; Immune system; Immunocompromised Host; Individual; Institution; Macaca mulatta; Modeling; Parvovirus; Pathogenicity; Persons; Plasma; Rate; Research; Research Personnel; Resources; Source; Symptoms; Uncertainty; United States National Institutes of Health; Virus; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Human Parvovirus 4 (PARV4) is a newly identified virus. The high seroconversion rates among adults suggests that this virus is very prevalent, and probably of low pathogenicity in persons with a normal immune system. However, there are doubts whether this virus causes symptoms in immunocompromised individuals. To determine whether a non-human primate model can be developed for PARV4, juvenile rhesus macaques were inoculated with PARV4-containing human plasma; one animal was also depleted of CD8+ cells prior to virus inoculation.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：人类细节病毒4（PARV4）是一种新鉴定的病毒。成年人的血清转化率高表明该病毒非常普遍，并且在患有正常免疫系统的人中可能具有低致病性。但是，有疑问，这种病毒是否会导致免疫功能低下的个体症状。为了确定是否可以针对PARV4开发非人类灵长类动物模型，将幼稚的猕猴接种了含PARV4的人血浆。在病毒接种之前，还将一种动物耗尽了CD8+细胞。