VENTILATION MODEL AND CNS INJURY IN BABOONS WITH BPD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 产前和新生儿护理方面的进步显著提高了早产儿的存活率，特别是最不成熟的婴儿。然而，随着这些儿童接近学龄，人们认识到多达50%的儿童面临神经行为挑战。所有这些神经行为缺陷背后的脑损伤的性质尚不完全清楚，但在脑白质中发现了常见的损伤模式，包括出血和囊性脑梗塞，称为脑室周围白质软化症(PVL)。人们也越来越认识到，在皮质和深部灰质以及海马体中存在初级或继发性损伤，这可能与随后的智力损害有关。至关重要的是，我们必须深入了解特定的新生儿做法，如呼吸支持，如何改变这些脆弱婴儿的脑损伤的性质和严重程度。在这项研究中，我们建议利用磁共振成像(MR)和组织病理学来研究早产灵长类动物模型(Papio Sp)作为支气管肺发育不良模型的脑损伤的性质。我们的假设是，早产的狒狒(Papio Sp)将表现出脑损伤的模式，这在磁共振成像和组织病理学上很明显，类似于在早产的人类婴儿中发现的模式。 具体目标#1：描述早产狒狒大脑发育的个体发育 具体目标#2：描述早产狒狒脑损伤的性质和严重程度。 具体目标#3：评估三种临床上高度相关的治疗方法对脑损伤模式的影响，这些方法包括一氧化氮、抗氧化剂和抗炎药物，目的是减少支气管肺发育不良(BPD)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Advances in prenatal and neonatal care have significantly improved survival of the prematurely born infant, particularly the most immature. However, as these children approach school age, it is recognized that up to 50% face neurobehavioral challenges. The nature of the cerebral injury that underlies all of these neurobehavioral deficits is not yet fully understood, but common patterns of injury are found in the cerebral white matter including hemorrhage and cystic infarction known as periventricular leukomalacia (PVL). It is also increasingly recognized that there is primary or secondary injury in the cortical and deep gray matter and the hippocampus, which may relate to subsequent intellectual impairments. It is critical that we gain insight into how particular neonatal practices, such as respiratory support, may alter the nature and the severity of cerebral injury in these vulnerable infants. In this study we propose to investigate the nature of cerebral injury in a prematurely born primate model (Papio sp) developed as a model of bronchopulmonary dysplasia, utilizing both magnetic resonance imaging (MR) and histopathology. Our hypothesis is that the prematurely born baboon (Papio sp) will display a pattern of cerebral injury, evident on MR imaging and histopathology, similar to that found in the prematurely born human infant. Specific aim #1: Characterize the ontogeny of cerebral development in the prematurely born baboon Specific aim #2: Characterize the nature and severity of cerebral injury in the prematurely born baboon. Specific aim #3: Evaluate the Influence of three highly clinically relevent therapies aimed at reducing bronchopulomonary dysplasia (BPD) on the pattern of cerebral injury including nitric oxide, antioxidant therapies and anti-inflammatory agents aimed at ductal closure.