VENTILATION MODEL AND CNS INJURY IN BABOONS WITH BPD

BPD 狒狒的通气模型和中枢神经系统损伤

• 批准号: 7716070
• 负责人: TERRIE E INDER
• 金额: $ 2.26万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716070
• 关键词: Anti-Inflammatory Agents; Bronchopulmonary Dysplasia; Caring; Cerebrum; Child; Closure; Computer Retrieval of Information on Scientific Projects Database; Depth; Development; Ductal; Dysplasia; Environmental air flow; Face; Funding; Grant; Growth; Hemorrhage; Hippocampus (Brain); Histopathology; Human; Image; Impairment; Infant; Infarction; Injury; Institution; Magnetic Resonance Imaging; Modeling; Nature; Neonatal; Nitric Oxide; Papio; Pattern; Periventricular Leukomalacia; Primates; Research; Research Personnel; Resources; School-Age Population; Severities; Source; United States National Institutes of Health; antioxidant therapy; central nervous system injury; gray matter; improved; insight; neurobehavioral; prenatal; respiratory; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Advances in prenatal and neonatal care have significantly improved survival of the prematurely born infant, particularly the most immature. However, as these children approach school age, it is recognized that up to 50% face neurobehavioral challenges. The nature of the cerebral injury that underlies all of these neurobehavioral deficits is not yet fully understood, but common patterns of injury are found in the cerebral white matter including hemorrhage and cystic infarction known as periventricular leukomalacia (PVL). It is also increasingly recognized that there is primary or secondary injury in the cortical and deep gray matter and the hippocampus, which may relate to subsequent intellectual impairments. It is critical that we gain insight into how particular neonatal practices, such as respiratory support, may alter the nature and the severity of cerebral injury in these vulnerable infants. In this study we propose to investigate the nature of cerebral injury in a prematurely born primate model (Papio sp) developed as a model of bronchopulmonary dysplasia, utilizing both magnetic resonance imaging (MR) and histopathology. Our hypothesis is that the prematurely born baboon (Papio sp) will display a pattern of cerebral injury, evident on MR imaging and histopathology, similar to that found in the prematurely born human infant. Specific aim #1: Characterize the ontogeny of cerebral development in the prematurely born baboon Specific aim #2: Characterize the nature and severity of cerebral injury in the prematurely born baboon. Specific aim #3: Evaluate the Influence of three highly clinically relevent therapies aimed at reducing bronchopulomonary dysplasia (BPD) on the pattern of cerebral injury including nitric oxide, antioxidant therapies and anti-inflammatory agents aimed at ductal closure.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 产前和新生儿护理方面的进步大大提高了早产儿，特别是最不成熟婴儿的存活率。然而，随着这些儿童接近学龄，人们认识到高达50%的儿童面临神经行为方面的挑战。作为所有这些神经行为缺陷的基础的脑损伤的性质尚未完全了解，但在脑白色物质中发现了常见的损伤模式，包括出血和称为脑室周围白质软化（PVL）的囊性梗死。人们也越来越多地认识到，在皮层和深层灰质和海马体中存在原发性或继发性损伤，这可能与随后的智力障碍有关。关键是，我们要深入了解新生儿的特殊做法，如呼吸支持，可能会改变这些脆弱的婴儿脑损伤的性质和严重程度。在这项研究中，我们建议调查的性质，脑损伤的早产灵长类动物模型（Papio SP）开发的支气管肺发育不良的模型，利用磁共振成像（MR）和组织病理学。我们的假设是，早产的狒狒（Papio sp）将显示一种脑损伤模式，在MR成像和组织病理学上很明显，与早产的人类婴儿相似。 具体目标#1：表征早产狒狒大脑发育的个体发生 具体目标#2：表征早产狒狒脑损伤的性质和严重程度。 具体目标3：评价旨在减少支气管肺发育不良（BPD）的三种高度临床相关治疗对脑损伤模式的影响，包括一氧化氮、抗氧化剂治疗和旨在关闭导管的抗炎药。