PROTECTION AGAINST RESPIRATORY PATHOGENS WITH OLIGONUCLEOTIDE CPG

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To test whether an oligonucleotide CpG can stimulate innate immune mechanisms in the respiratory tract that can protect against an acute respiratory mucosal challenge with measles virus in the rhesus monkey. A secondary objective will be to determine whether CpG priming of innate immunity can augment the adaptive immune response to measles virus following a respiratory challenge.