PROTECTION AGAINST RESPIRATORY PATHOGENS WITH OLIGONUCLEOTIDE CPG

使用寡核苷酸 CPG 预防呼吸道病原体

• 批准号: 7562186
• 负责人: Arthur M. Krieg
• 金额: $ 10.66万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562186
• 关键词: Acute; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Immune; Immune response; Institution; Macaca mulatta; Measles virus; Natural Immunity; Oligonucleotides; Research; Research Personnel; Resources; Respiratory System; Source; Testing; United States National Institutes of Health; pathogen; respiratory

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To test whether an oligonucleotide CpG can stimulate innate immune mechanisms in the respiratory tract that can protect against an acute respiratory mucosal challenge with measles virus in the rhesus monkey. A secondary objective will be to determine whether CpG priming of innate immunity can augment the adaptive immune response to measles virus following a respiratory challenge.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：测试寡核苷酸CpG是否可以刺激呼吸道中的先天免疫机制，从而保护恒河猴免受麻疹病毒的急性呼吸道粘膜攻击。第二个目标是确定先天免疫的CpG引发是否可以增强呼吸道激发后对麻疹病毒的适应性免疫应答。