PROTECTION AGAINST RESPIRATORY PATHOGENS WITH OLIGONUCLEOTIDE CPG

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。目的：研究一种寡核苷酸CpG是否能刺激呼吸道先天免疫机制，从而保护恒河猴免受麻疹病毒急性呼吸道粘膜攻击。第二个目的是确定先天性免疫的CpG启动是否可以增强呼吸道攻击后对麻疹病毒的适应性免疫反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To test whether an oligonucleotide CpG can stimulate innate immune mechanisms in the respiratory tract that can protect against an acute respiratory mucosal challenge with measles virus in the rhesus monkey. A secondary objective will be to determine whether CpG priming of innate immunity can augment the adaptive immune response to measles virus following a respiratory challenge.