PROTECTION AGAINST RESPIRATORY PATHOGENS WITH OLIGONUCLEOTIDE CPG

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目的：检测寡核苷酸CpG能否刺激呼吸道天然免疫机制，从而保护呼吸道粘膜免受麻疹病毒的急性攻击。第二个目标将是确定CpG先天免疫是否可以增强呼吸道挑战后对麻疹病毒的适应性免疫反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To test whether an oligonucleotide CpG can stimulate innate immune mechanisms in the respiratory tract that can protect against an acute respiratory mucosal challenge with measles virus in the rhesus monkey. A secondary objective will be to determine whether CpG priming of innate immunity can augment the adaptive immune response to measles virus following a respiratory challenge.