Metformin in Gestational Diabetes: follow-up of mothers and offspring: body composition, insulin resistance, development

二甲双胍治疗妊娠糖尿病：母亲和后代的随访：身体成分、胰岛素抵抗、发育

• 批准号: nhmrc : 508061
• 负责人: A/Pr Ross Haslam
• 金额: $ 42.02万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/metformin-gestational-diabetes-resistance-development/97015
• 关键词: Metformin; Gestational; Diabetes; follow; up

Children born to women with gestational diabetes are at increased risk of later obesity and diabetes. This study will help to assess if giving such women during their pregnancy the cheap oral diabetes drug metformin rather than insulin injections can safely reduce this risk, measuring growth, fatness and blood glucose-insulin in the children at 2 and 5 years of age, as well as assessing the mothers. If so, such treatment might help to reduce the worldwide burden of disease related to obesity.

患有妊娠糖尿病的妇女所生的孩子日后患肥胖症和糖尿病的风险增加。这项研究将有助于评估在怀孕期间给予这些妇女廉价的口服糖尿病药物二甲双胍而不是胰岛素注射剂是否可以安全地降低这种风险，测量2岁和5岁儿童的生长，肥胖和血糖-胰岛素，以及评估母亲。如果是这样的话，这种治疗可能有助于减少全球与肥胖有关的疾病负担。