Accuracy of Self-Reported Prenatal Smoking in Child Cancer Epidemiology Studies

描述(由申请人提供)： 摘要这项拟议的研究将探索现有样本中可替宁(吸烟的一个客观生物标志物)的存在/数量与报告的烟草使用之间的关系，该样本与经常用于流行病学研究(包括儿童癌症研究)的广泛可用的大型数据集相关联。烟草成分会穿过胎盘，并可能使怀孕面临包括儿童癌症在内的不良后果的风险。因此，癌症病因学的流行病学研究经常获得有关吸烟的数据，几乎总是通过自我报告。由于社会需要，或者因为数据是在确诊多年后收集的，个人可能会不准确地报告吸烟者的状况。出生记录是许多结果研究的重要数据来源，相关的癌症登记-出生记录正越来越多地被用于儿童癌症的协作性病例对照研究。一个好处是出生记录上的产前吸烟信息是在疾病诊断之前和怀孕附近获得的。我们建议使用新开发的实验室方法结合新生儿筛查档案中的干血迹(DBS)来评估出生记录中自我报告的母亲产前吸烟信息的准确性。我们建议对华盛顿州2008年出生记录中确定的200名婴儿的DBS样本中的可替宁进行测量：100名出生在随机选择的自称在怀孕期间吸烟的妇女，100名出生在不吸烟的人(从4个不同的吸烟量水平中随机选择25个)。具体地说，我们建议：1)通过剂量(每天1-9支、10-19支、10-19支、30支以上)和持续时间(部分与全部怀孕)描述报告的非吸烟者和吸烟者中可替宁的存在和水平，以及2)通过将这些信息与DBS中的可替宁水平进行比较来评估自我报告的产前吸烟状态(是/否)的有效性。这些信息对未来的儿童癌症研究将是重要的，越来越多的儿童癌症研究正在获取存档的DBS作为基因研究的DNA来源，DBS还可能为其提供环境暴露的生物标记物。 公共卫生相关性： 项目简介：在儿童癌症流行病学研究中，评估吸烟是一个危险因素是困难的。我们建议通过比较200名报告吸烟者和出生记录中确定的非吸烟者所生婴儿干血斑中的可替宁(吸烟的生物标志物)水平来衡量自我报告的产前吸烟信息的准确性。这些信息可能有助于改进对儿童癌症和其他结果的研究，如畸形和婴儿猝死综合症。

DESCRIPTION (provided by applicant): ABSTRACT This proposed study will explore the relationship between reported tobacco use and presence/amount of cotinine (an objective biomarker of smoking) in existing specimens linked to a large, widely available dataset often used for epidemiologic research, including for childhood cancer studies. Tobacco constituents cross the placenta, and may place pregnancies at risk of adverse outcomes including childhood cancer. Thus, epidemiologic studies of cancer etiology routinely obtain data about smoking, virtually always by self-report. Individuals may inaccurately report smoker status due to social desirability, or because data are collected many years after diagnosis. Birth records are an important data source for studies of many outcomes, and linked cancer registry-birth records are increasingly being used in collaborative case-control studies of childhood cancer. One advantage is that prenatal smoking information on birth records is obtained prior to disease diagnosis, and near the pregnancy. We propose to assess the accuracy of self-reported maternal prenatal smoking information in the birth record, by using newly developed laboratory methods in combination with dried blood spots (DBS) from newborn screening archives. We propose to measure the cotinine in DBS specimens for 200 infants identified in Washington State birth records from 2008: 100 born to randomly selected women who indicated they smoked during pregnancy, and 100 born to non-smokers (25 randomly selected from each of 4 different smoking dose levels). Specifically, we propose to: 1) Describe the presence and levels of cotinine among reported non-smokers and smokers, and among smokers by dose (1-9, 10-19, 10-19, 30+ cigarettes/day) and duration (part vs. all of pregnancy), and 2) Assess the validity of self-reported prenatal smoking status (yes/no) by comparing this information to cotinine levels in DBS. This information will be important for future childhood cancer studies, which increasingly are accessing archived DBS as a source of DNA for gene studies, and for which DBS may also provide biomarkers of environmental exposures. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE: Assessing smoking as a risk factor in epidemiology studies of childhood cancer is difficult. We propose to measure the accuracy of self-reported prenatal smoking information by comparing levels of cotinine (a biomarker of cigarette smoking) in dried blood spots of 200 infants born to reported smokers and non-smokers identified in birth records. This information may help improve studies of childhood cancer and other outcomes such as malformations and Sudden Infant Death Syndrome.