Accuracy of Self-Reported Prenatal Smoking in Child Cancer Epidemiology Studies

描述（由申请人提供）： 摘要本研究将探讨现有样本中报告的烟草使用与可替宁（吸烟的客观生物标志物）的存在/量之间的关系，该样本与流行病学研究（包括儿童癌症研究）经常使用的大量广泛可用的数据集相关。烟草成分穿过胎盘，可能会使怀孕面临不良后果的风险，包括儿童癌症。因此，癌症病因学的流行病学研究通常通过自我报告获得有关吸烟的数据。个人可能会不准确地报告吸烟者的状态，由于社会需求，或因为数据是在诊断后多年收集的。出生记录是许多结果研究的重要数据来源，并且关联的癌症登记出生记录越来越多地用于儿童癌症的协作病例对照研究。一个优点是，出生记录上的产前吸烟信息是在疾病诊断之前和怀孕前后获得的。我们建议使用新开发的实验室方法结合新生儿筛查档案中的干血斑（DBS），评估出生记录中自我报告的孕产妇产前吸烟信息的准确性。我们建议测量2008年华盛顿州出生记录中确定的200名婴儿DBS标本中的可替宁：100名出生于随机选择的妊娠期间吸烟的女性，100名出生于非吸烟者（从4个不同吸烟剂量水平中随机选择25名）。具体而言，我们建议：1）按剂量（1-9、10- 1 -9、10 - 1 - 9、30+支/天）和持续时间（部分与全部妊娠）描述报告的非吸烟者和吸烟者以及吸烟者中可替宁的存在和水平，2）通过将此信息与DBS中的可替宁水平进行比较，评估自我报告的产前吸烟状态（是/否）的有效性。这些信息对于未来的儿童癌症研究将是重要的，这些研究越来越多地将存档的DBS作为基因研究的DNA来源，并且DBS还可以提供环境暴露的生物标志物。 公共卫生相关性： 项目叙述：在儿童癌症的流行病学研究中，评估吸烟作为危险因素是困难的。我们建议通过比较200名出生于出生记录中报告的吸烟者和非吸烟者的婴儿的干血斑中可替宁（吸烟的生物标志物）的水平来测量自我报告的产前吸烟信息的准确性。这些信息可能有助于改善儿童癌症和其他结果的研究，如畸形和婴儿猝死综合征。

DESCRIPTION (provided by applicant): ABSTRACT This proposed study will explore the relationship between reported tobacco use and presence/amount of cotinine (an objective biomarker of smoking) in existing specimens linked to a large, widely available dataset often used for epidemiologic research, including for childhood cancer studies. Tobacco constituents cross the placenta, and may place pregnancies at risk of adverse outcomes including childhood cancer. Thus, epidemiologic studies of cancer etiology routinely obtain data about smoking, virtually always by self-report. Individuals may inaccurately report smoker status due to social desirability, or because data are collected many years after diagnosis. Birth records are an important data source for studies of many outcomes, and linked cancer registry-birth records are increasingly being used in collaborative case-control studies of childhood cancer. One advantage is that prenatal smoking information on birth records is obtained prior to disease diagnosis, and near the pregnancy. We propose to assess the accuracy of self-reported maternal prenatal smoking information in the birth record, by using newly developed laboratory methods in combination with dried blood spots (DBS) from newborn screening archives. We propose to measure the cotinine in DBS specimens for 200 infants identified in Washington State birth records from 2008: 100 born to randomly selected women who indicated they smoked during pregnancy, and 100 born to non-smokers (25 randomly selected from each of 4 different smoking dose levels). Specifically, we propose to: 1) Describe the presence and levels of cotinine among reported non-smokers and smokers, and among smokers by dose (1-9, 10-19, 10-19, 30+ cigarettes/day) and duration (part vs. all of pregnancy), and 2) Assess the validity of self-reported prenatal smoking status (yes/no) by comparing this information to cotinine levels in DBS. This information will be important for future childhood cancer studies, which increasingly are accessing archived DBS as a source of DNA for gene studies, and for which DBS may also provide biomarkers of environmental exposures. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE: Assessing smoking as a risk factor in epidemiology studies of childhood cancer is difficult. We propose to measure the accuracy of self-reported prenatal smoking information by comparing levels of cotinine (a biomarker of cigarette smoking) in dried blood spots of 200 infants born to reported smokers and non-smokers identified in birth records. This information may help improve studies of childhood cancer and other outcomes such as malformations and Sudden Infant Death Syndrome.