BSL4 Core

BSL4 核心

• 批准号: 7649747
• 负责人: Clarence J. Peters
• 金额: $ 19.1万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7649747
• 关键词: Aerosols; Animal Model; Animals; Biomedical Research; Containment; Diagnostic; Evaluation; Foundations; Housing; Knowledge; Laboratories; Mechanics; Medical; Microbiology; Modeling; Multi-Drug Resistance; Operative Surgical Procedures; Purpose; Research; Research Infrastructure; Research Personnel; Rodent; Sampling; Schedule; Scientist; Testing; Texas; Therapeutic; Training; Universities; Vaccines; Viral Hemorrhagic Fevers; Work; Workplace; experience; hemorrhagic fever virus; nonhuman primate; pathogenic bacteria; research study; therapeutic vaccine

This BSL-4 core provides the infrastructure to permit safe work to be performed on aerosol-infectious, potentially lethal agents. It consists of the mechanical safeguards of two high-containment laboratories, the provision of training in BSL-4 operations, and assistance in operations within the laboratories. Generally, the investigators will work within the laboratory, but about 20% of the effort will be devoted to challenge experiments using established animal models to test newly developed vaccines and therapeutics. Part of this core is located at Southwest Foundation for Biomedical Research (SF BR) in San Antonio, TX where 1200 ft 2 of BSL-4 laboratory space is available. The other component is scheduled for completion in June, 2003 and will provide 2000 ft 2 at the University of Texas Medical Branch, Galveston, TX. The SFBR facility has been in operation since March of 2000 and provides space for microbiological operations as well as housing for rodents and small non-human primates. UTMB will have 1000 ft 2devoted primarily to animals and 1000 ft 2 mainly used to for microbiology. Both have access to a high intensity gamma irradiator allowing inactivation of samples for further analysis outside the BSL-4 laboratory. This core is essential for work on the hemorrhagic fever viruses and multidrug resistant highly pathogenic bacteria.

该BSL-4核心提供了基础设施，以允许对气溶胶传染性， 潜在的致命物质它包括两个高密封实验室的机械保障， 提供BSL-4操作培训，并协助实验室内的操作。一般而言， 研究人员将在实验室内工作，但约20%的工作将用于挑战 使用已建立的动物模型进行实验，以测试新开发的疫苗和疗法。的一部分 该核心位于德克萨斯州圣安东尼奥的西南生物医学研究基金会（SF BR）， 1200英尺2的BSL-4实验室空间可用。另一部分定于6月完成， 2003年，并将在德克萨斯州加尔维斯顿的德克萨斯大学医学分支提供2000英尺2。SFBR设施 自2000年3月以来一直在运行，为微生物操作提供空间， 啮齿动物和小型非人类灵长类动物的住所。UTMB将有1000英尺2主要用于动物 1000平方英尺主要用于微生物学。两者都可以使用高强度伽马辐照器， 在BSL-4实验室外对样品进行进一步分析。这一核心对于以下工作至关重要： 出血热病毒和多重耐药高致病性细菌。