LEGACY: A Pilot Study to Establish a Youth Cohort in the Breast CFR

遗产：建立乳腺 CFR 青年队列的试点研究

• 批准号: 7741009
• 负责人: ESTHER M. JOHN
• 金额: $ 7.25万
• 依托单位: CANCER PREVENTION INSTIT OF CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7741009
• 关键词: Adolescence; Adolescent; Adult; Age; Age at Menarche; American; Anthropometry; Area; Biological Markers; Birth; Body Size; Breast; California; Characteristics; Child; Collection; DNA Methylation; Data; Daughter; Development; Diet; Enrollment; Environmental Exposure; Epigenetic Process; Ethnic Origin; Etiology; Exposure to; Family; Family history of; Friends; Funding; Future; Genes; Genetic; Genetic Variation; Hormones; Interview; Life; Life Style; Link; Malignant Neoplasms; Mammary Gland Parenchyma; Measurement; Menarche; Molecular; Mothers; Names; Obesity; Optics; Parents; Perinatal; Perinatal Exposure; Physical activity; Pilot Projects; Play; Preparation; Prevalence; Procedures; Questionnaires; Race; Recruitment Activity; Risk; Risk Factors; Role; Sampling; San Francisco; Self-Administered; Sex Characteristics; Site; Social Environment; Socioeconomic Status; Somatotropin; Spectrum Analysis; Testing; Time; Youth; aged; breast cancer diagnosis; breast cancer family; breast cancer family registry; cancer initiation; cancer risk; cohort; design; experience; follow-up; genetic epidemiology; girls; innovation; lifestyle factors; malignant breast neoplasm; public health relevance; sex

DESCRIPTION (provided by applicant): Epidemiologic evidence is accumulating that early-life factors may play an important role in the etiology of breast cancer. Children and adolescents may be particularly sensitive to exposures that are associated with breast cancer initiation or protection against breast cancer, thus presenting new windows of opportunity to potentially modify breast cancer risk at a young age. Identification of modifiable early-life risk factors is particularly important for girls from breast cancer families as they are at increased risk of developing breast cancer, given their family history. We are planning to establish a multi-center cohort of 1,600 girls aged 6-17 years and follow them prospectively in order to study early-life exposures (perinatal, lifestyle, and environmental exposures), as well as genetic and epigenetic factors and their effects on several endpoints related to pubertal development, including age at menarche, breast development, breast tissue characteristics, and sex and growth hormones. The cohort, named LEGACY (Lessons in Epidemiology and Genetics of Adult Cancer from Youth), will consist of girls and their mothers who are enrolled in the Breast Cancer Family Registry (BCFR) and, for comparison, girls and their mothers identified through friend controls. Thus, the cohort will be enriched with girls at increased breast cancer risk, given their family history. In preparation for establishing such a cohort, we propose to pilot test the baseline and 6-months follow-up procedures in order to 1) demonstrate feasibility of recruitment and retention in the cohort, and 2) obtain preliminary data on prevalence and variability of key endpoint and exposure variables. We will build upon a small pilot study and recruit an additional 50 girls and their mothers (30 BCFR girls and 20 friend control girls) from the San Francisco Bay area. The baseline assessment includes an interview and self-administered questionnaire, anthropometric measurements, collection of biospecimen samples, and a 7-day pedometry study. Data and biospecimen collection will be repeated 6 months after the baseline assessment. Experience gained from this pilot study will be essential for the planning and establishment of the full cohort. PUBLIC HEALTH RELEVANCE: We propose to conduct a pilot study with 50 girls aged 6-17 years and their mothers in order to demonstrate the feasibility of recruitment and retention. Experience gained from this pilot study will help establish a cohort of 1,600 girls that will be followed for 5 years in order to study early-life exposures and their effects on pubertal development.

描述(由申请人提供)： 越来越多的流行病学证据表明，早期生命因素可能在乳腺癌的病因中发挥重要作用。儿童和青少年可能对与乳腺癌启动或预防乳腺癌相关的暴露特别敏感，从而为在年轻时潜在地改变乳腺癌风险提供了新的机会之窗。对于来自乳腺癌家庭的女孩来说，确定可改变的早期生活风险因素特别重要，因为鉴于她们的家族病史，她们患乳腺癌的风险更高。我们计划建立一个由1600名6-17岁女孩组成的多中心队列，并对她们进行前瞻性跟踪，以研究早期生命暴露(围产期、生活方式和环境暴露)，以及遗传和表观遗传因素及其对与青春期发育相关的几个终点的影响，包括月经初潮年龄、乳房发育、乳房组织特征、性激素和生长激素。该队列名为LEGISE(青少年成人癌症流行病学和遗传学课程)，将包括在乳腺癌家庭登记(BCFR)登记的女孩和她们的母亲，作为比较，女孩和她们的母亲是通过朋友对照确定的。因此，考虑到她们的家族史，这一队列中将有更多患乳腺癌风险更高的女孩。为了准备建立这样一个队列，我们提议试行基线和为期6个月的后续程序，以便1)证明在队列中招募和保留的可行性，以及2)获得关于关键终点和暴露变量的流行率和变异性的初步数据。我们将在一项小型试点研究的基础上，从旧金山湾区再招募50名女孩和她们的母亲(30名BCFR女孩和20名朋友控制女孩)。基线评估包括访谈和自我管理的问卷、人体测量、生物样本的收集和7天的计步法研究。数据和生物量收集将在基线评估后6个月重复进行。从这项试点研究中获得的经验将对整个队列的规划和建立至关重要。 公共卫生相关性： 我们建议对50名6-17岁的女孩及其母亲进行一项试点研究，以证明招募和保留的可行性。从这项试点研究中获得的经验将有助于建立一个1600名女孩的队列，该队列将被跟踪5年，以研究早期接触及其对青春期发育的影响。