Population Sciences

项目总结 斯坦福大学癌症研究所(SCI)人口科学计划(PS)的目标是进行高- 跨癌症的跨学科和转化性研究旨在提高检测水平 通过筛查，降低癌症发病率、发病率和死亡率，并改善癌症结果。The PS 通过促进和促进创新的多学科观察性和干预性来实现这一目标 对癌症的研究将影响公众健康，并指导临床实践和卫生政策。PS成员是 具有广泛独特优势的国内和国际公认的临床和人口科学家 在流行病学、遗传学、定量建模、生物信息学、新技术的使用、行为科学、 生活方式(体力活动、饮食、控烟、睡眠)、临床和姑息治疗干预试验，以及 社区卫生和预防研究。该计划的首要研究重点包括减少 癌症负担和差异(按年龄、性别和性别、种族和民族、社会经济地位、地理位置、 和其他健康的社会决定因素)在SCI集水区高度多样化的人口中。 PS成员的研究涉及以下具体目标：目标1：进行癌症病因学、风险研究 预测、筛查和基因测试；目标2：调查癌症治疗和预后的影响 影响结果的因素；以及目标3：开展干预研究以降低癌症风险和改善结果。 PS有39名成员，其中31名由同行审查资助，总额为1400万美元，其中包括740万美元 来自NCI的500万美元其他与癌症相关的NIH支持，以及来自其他同行评议支持的160万美元。在.期间 在目前的资助期内，社会保障局成员发表了1130份同行评议的手稿。其中，22%是内部的 计划性的，23%是跨计划的，96%是多机构的，18%是有影响的期刊 因数为10或更高。SCI的支持有助于促进内部和外部的 PS成员的计划协作，招聘新的教员，并支持初步研究 通过创新赠款引导外部资助的项目。PS成员也在努力培训下一位 一代癌症预防研究人员。未来，PS将进一步扩大并专注于 整个生命过程中的遗传风险描述和评估，结果和生存研究，癌症 性少数群体和性别少数群体以及保健服务和执行科学，并将制定和提交一份 遗传流行病学和人口科学方面的T32培训补助金。

PROJECT SUMMARY The goal of the Population Sciences Program (PS) of the Stanford Cancer Institute (SCI) is to conduct high- impact transdisciplinary and translational research across the cancer continuum aimed at improving detection through screening, reducing cancer incidence, morbidity and mortality, and improving cancer outcomes. The PS achieves this goal by promoting and facilitating innovative multidisciplinary observational and interventional research on cancer that will impact public health and guide clinical practice and health policy. PS members are nationally and internationally recognized clinical and population scientists with a broad range of unique strengths in epidemiology, genetics, quantitative modeling, bioinformatics, use of novel technologies, behavioral science, lifestyle (physical activity, diet, tobacco control, sleep), and clinical and palliative care interventional trials, and community health and prevention research. The program’s overarching research priorities include reducing the cancer burden and disparities (by age, sex and gender, race and ethnicity, socioeconomic status, geography, and other social determinants of health) in the highly diverse population of SCI’s catchment area. PS members’ research addresses the following Specific Aims: Aim 1: Conduct research on cancer etiology, risk prediction, screening, and genetic testing; Aim 2: Investigate the impact of cancer treatment and prognostic factors on outcomes; and Aim 3: Conduct intervention research to reduce cancer risks and improve outcomes. The PS has 39 members, of whom 31 are supported by peer-reviewed funding totaling $14.0M, including $7.4M from the NCI, $5.0M other cancer-relevant NIH support, and $1.6M from other peer-reviewed support. During the current funding period, PS members published 1,130 peer-reviewed manuscripts. Of these, 22% are intra- programmatic, 23% are inter-programmatic, 96% are multi-institutional, and 18% are in journals with an impact factor of 10 or higher. Support from the SCI has been instrumental in promoting both intra- and inter- programmatic collaborations of PS members, recruiting new faculty members, and enabling preliminary research through innovation grants that lead to externally funded projects. PS members also strive to train the next generation of cancer prevention researchers. In the future, the PS will further expand and focus on research in genetic risk profiling and assessment, outcomes and survivorship research across the life course, cancer in sexual and gender minorities, and health services and implementation science, and will develop and submit a T32 training grant in genetic epidemiology and population sciences.