Population Sciences

项目摘要 斯坦福大学癌症研究所（SCI）人口科学计划（PS）的目标是进行高水平的 影响跨学科和跨癌症连续体的转化研究，旨在改善检测 通过筛查，降低癌症发病率、发病率和死亡率，改善癌症预后。的PS 通过促进和促进创新的多学科观察和干预来实现这一目标 癌症研究将影响公共卫生，并指导临床实践和卫生政策。PS成员为 国内和国际公认的临床和人口科学家，具有广泛的独特优势 在流行病学、遗传学、定量建模、生物信息学、新技术的使用、行为科学、 生活方式（体力活动、饮食、烟草控制、睡眠）以及临床和姑息治疗干预试验，以及 社区卫生和预防研究。该计划的首要研究重点包括减少 癌症负担和差异（按年龄，性别和性别，种族和民族，社会经济地位，地理， 和其他健康的社会决定因素）在SCI的集水区高度多样化的人口。 参与者的研究主要针对以下具体目标：目标1：进行癌症病因学、风险 预测、筛查和基因检测;目的2：研究癌症治疗和预后的影响 目标3：开展干预研究，以降低癌症风险并改善结果。 PS有39名成员，其中31人得到了同行评审资金的支持，总额为1400万美元，其中包括740万美元 来自NCI的500万美元，其他癌症相关NIH支持，以及来自其他同行评审支持的160万美元。期间 在当前的资助期内，PS成员发表了1，130篇同行评审的手稿。其中，22%是在... 计划，23%是跨计划，96%是多机构，18%是有影响力的期刊 10倍或更高。SCI的支持有助于促进内部和内部 PS成员的计划合作，招募新的教师，并使初步研究 通过创新赠款，导致外部资助的项目。PS成员也努力培养下 一代癌症预防研究人员。未来，PS将进一步扩大并专注于以下方面的研究 遗传风险分析和评估，整个生命过程中的结果和生存研究， 性和性别少数群体，卫生服务和实施科学，并将制定和提交一份 遗传流行病学和人口科学培训补助金。

PROJECT SUMMARY The goal of the Population Sciences Program (PS) of the Stanford Cancer Institute (SCI) is to conduct high- impact transdisciplinary and translational research across the cancer continuum aimed at improving detection through screening, reducing cancer incidence, morbidity and mortality, and improving cancer outcomes. The PS achieves this goal by promoting and facilitating innovative multidisciplinary observational and interventional research on cancer that will impact public health and guide clinical practice and health policy. PS members are nationally and internationally recognized clinical and population scientists with a broad range of unique strengths in epidemiology, genetics, quantitative modeling, bioinformatics, use of novel technologies, behavioral science, lifestyle (physical activity, diet, tobacco control, sleep), and clinical and palliative care interventional trials, and community health and prevention research. The program’s overarching research priorities include reducing the cancer burden and disparities (by age, sex and gender, race and ethnicity, socioeconomic status, geography, and other social determinants of health) in the highly diverse population of SCI’s catchment area. PS members’ research addresses the following Specific Aims: Aim 1: Conduct research on cancer etiology, risk prediction, screening, and genetic testing; Aim 2: Investigate the impact of cancer treatment and prognostic factors on outcomes; and Aim 3: Conduct intervention research to reduce cancer risks and improve outcomes. The PS has 39 members, of whom 31 are supported by peer-reviewed funding totaling $14.0M, including $7.4M from the NCI, $5.0M other cancer-relevant NIH support, and $1.6M from other peer-reviewed support. During the current funding period, PS members published 1,130 peer-reviewed manuscripts. Of these, 22% are intra- programmatic, 23% are inter-programmatic, 96% are multi-institutional, and 18% are in journals with an impact factor of 10 or higher. Support from the SCI has been instrumental in promoting both intra- and inter- programmatic collaborations of PS members, recruiting new faculty members, and enabling preliminary research through innovation grants that lead to externally funded projects. PS members also strive to train the next generation of cancer prevention researchers. In the future, the PS will further expand and focus on research in genetic risk profiling and assessment, outcomes and survivorship research across the life course, cancer in sexual and gender minorities, and health services and implementation science, and will develop and submit a T32 training grant in genetic epidemiology and population sciences.