Preeclampsia and subsequent breast cancer risk: hormonal and growth factor biomar

先兆子痫和随后的乳腺癌风险：激素和生长因子生物标志物

• 批准号: 7589425
• 负责人: Michele Robin Forman
• 金额: $ 7.7万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7589425
• 关键词: Age; Androgens; Androstenedione; Binding Proteins; Birth; Blood; Body mass index; Breast Feeding; Child; Data; Daughter; Diagnosis; Estradiol; Estrogens; Estrone; Gender; Growth Factor; Hormonal; Hormones; Hospitals; Inorganic Sulfates; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Leptin; Measures; Menstrual cycle; Norway; Phase; Postpartum Period; Pre-Eclampsia; Pregnancy; Premenopause; Progesterone; Recording of previous events; Risk; Serum; Sex Hormone-Binding Globulin; Smoking Status; Son; Specimen; Testing; Testosterone; Umbilical Cord Blood; Unspecified or Sulfate Ion Sulfates; Woman; Women' s Group; abstracting; base; cancer risk; indexing; interest; malignant breast neoplasm; offspring; reproductive

DESCRIPTION (provided by applicant): Layman's abstract: Women with a history of preeclampsia in pregnancy are at reduced risk of breast cancer, especially those who delivered a son, not a daughter, from the pregnancy. Why is this so? We compare hormones in the blood of a group of women who had been diagnosed with preeclampsia in pregnancy to hormones in a group who had normal pregnancies, after taking into consideration their age and other factors that influence hormone levels. We hypothesize that women with a history of preeclampsia will have lower estrogens and growth factors related to breast cancer than women who had normal pregnancies.

描述（由申请人提供）： Layman的摘要：有先兆子痫病史的妇女患乳腺癌的风险降低，特别是那些从怀孕中生下儿子而不是女儿的妇女。为什么会这样呢？我们比较了一组在怀孕期间被诊断患有先兆子痫的妇女血液中的激素与一组正常怀孕的妇女的激素，考虑了她们的年龄和其他影响激素水平的因素。我们假设有先兆子痫病史的妇女与正常妊娠的妇女相比，与乳腺癌相关的雌激素和生长因子水平较低。