Colon Cancer Chemoprevention by Dietary Resveratrol

描述(由申请人提供)： 患有炎症性肠病[溃疡性结肠炎(UC)和克罗恩病(CD)]的人患结肠癌的风险很高。结肠炎的常规治疗可以减少活动期并保持缓解，但治疗结果往往微乎其微，患者变得难以治愈，而且存在危险的副作用。因此，补充和替代疗法在减轻活动性疾病症状方面仍然很有希望。据估计，40%的炎症性肠病(IBD)患者使用某种形式的甲基维他命治疗或草药/膳食补充剂。白藜芦醇(3，4‘，5-三羟基-反式二苯乙烯)是一种天然存在的多酚类化合物，具有抗氧化、抗炎、心脏保护和抗癌等多种保健作用。它很快就被认为是在预防和治疗癌症方面更有前途的天然分子之一。我们和另一个小组已经证明，口服白藜芦醇可以缓解动物的结肠炎。这些研究首次提供了白藜芦醇可能有效治疗IBD的原则证明，我们现在假设这将防止结肠癌的后续发展。这些研究应该提供重要的新数据，以确定这种天然化合物是否提供了一种新的安全方法，将有助于预防结肠癌的发展。

DESCRIPTION (provided by applicant): People with inflammatory bowel disease [ulcerative colitis (UC) and Crohn's disease (CD)] have a high colon cancer risk. Conventional treatment of colitis can reduce periods of active disease and maintain remission, but treatment outcomes are often marginal; patients become refractory; and there are dangerous side effects. Thus, complementary and alternative treatments remain promising for abating symptoms of active disease. An estimated 40% of inflammatory bowel disease (IBD) patients use some form of megavitamin therapy or herbal/dietary supplement. Resveratrol (3,4',5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits pleiotropic health beneficial effects including anti-oxidant, anti-inflammatory, cardioprotective and anti-cancer activities. It is quickly being recognized as one of the more promising natural molecules in the prevention and treatment of cancer. We and one other group have demonstrated that oral administration of resveratrol alleviates colitis in animals. These studies have provided the first proof-of-principle demonstration that resveratrol may be effective in the treatment of IBD, and we now hypothesize that this will prevent the subsequent development of colon cancer. These studies should provide important new data that will determine if this natural compound provides a new and safe approach that will be useful in preventing the development of colon cancer.