Methylation and the risk of urothelial cell cancer

甲基化与尿路上皮细胞癌的风险

• 批准号: nhmrc : 1043616
• 负责人: Dr Daniel Schmidt
• 金额: $ 46.92万
• 依托单位: Cancer Council Victoria
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/methylation-risk-urothelial-cell-cancer/111588
• 关键词: Methylation; risk; urothelial; cell; cancer

Why don’t we run prevention programs for urinary tract cancers like we do for others? It’s because we don’t know which lifestyle factors, except smoking, are important to cancers of the renal pelvis, ureters, bladder and urethra. We plan to use new technology to measure the ‘epigenome’, the part of the genome that turns genes on or off. This may explain how lifestyle factors influence what genes do, and we hope our findings will help to develop future prevention strategies for these cancers.

为什么我们不像对其他人那样开展尿道癌的预防项目呢？这是因为我们不知道除吸烟外，哪些生活方式因素对肾盆癌、输尿管癌、膀胱癌和尿道癌有重要影响。我们计划使用新技术来测量“表观基因组”，这是基因组中开启或关闭基因的部分。这可能解释了生活方式因素如何影响基因的作用，我们希望我们的发现将有助于开发未来对这些癌症的预防策略。