Microarray-targeted candidate gene approach to finding ovarian cancer susceptibility genes

微阵列靶向候选基因方法寻找卵巢癌易感基因

• 批准号: nhmrc : 389867
• 负责人: A/Pr Dorota Gertig
• 金额: $ 40.87万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microarray-targeted-candidate-susceptibility-genes/81500
• 关键词: Microarray; targeted; candidate; gene; approach

We propose that subtle, heritable changes in the expression or function of genes that are switched off, or on, early in the development of ovarian tumours, may predispose the individual to ovarian cancer. We will are carry out a large study of the most common subtype of ovarian adenocarcinoma, serous invasive tumors, in order to identify genes that affect a woman's risk of ovarian cancer. Identification of women at elevated risk for ovarian cancer on the basis of their genotype will allow them to be targeted for screening, and for intervention studies, as well as providing fundamental insight into the etiology of ovarian cancer.

我们认为，在卵巢肿瘤发生的早期，关闭或打开的基因的表达或功能发生微妙的、可遗传的变化，可能使个体容易患卵巢癌。我们将对卵巢腺癌最常见的亚型浆液性浸润性肿瘤进行一项大型研究，以确定影响女性患卵巢癌风险的基因。根据基因型识别卵巢癌高风险女性将使她们成为筛查和干预研究的目标，并为卵巢癌的病因学提供基本见解。