Error Sensitivity as a Predictor of Nicotine Withdrawal & Smoking Cessation

误差敏感性作为尼古丁戒断的预测指标

• 批准号: 7641972
• 负责人: PAUL MICHAEL CINCIRIPINI
• 金额: $ 21.46万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7641972
• 关键词: Abstinence; Acute; Affect; Animals; Anterior; Area; Asses; Awareness; Behavior; Behavior monitoring; Behavioral; Cessation of life; Chronic; Cognitive; Counseling; Couples; Cues; Data; Development; Drug Formulations; Drug abuse; Drug usage; Electroencephalography; Event; Event-Related Potentials; Feedback; Future; Goals; Hand; Health; Hypersensitivity; Image; Impairment; Individual; Intervention; Laboratories; Literature; Maps; Measures; Medial; Modeling; Monitor; Motivation; Neurobiology; Nicotine; Nicotine Dependence; Nicotine Withdrawal; Outcome; Participant; Pattern; Pharmaceutical Preparations; Plants; Prefrontal Cortex; Procedures; Process; Property; Reading; Refractory; Relapse; Relative (related person); Research Design; Resources; Rewards; Risk; Sampling; Sensory; Short-Term Memory; Smoke; Smoker; Smoking; Smoking Behavior; Source; Stimulus; Stress; System; Testing; Time; Treatment outcome; Woman; base; cigarette smoking; cingulate cortex; cognitive control; cognitive system; deprivation; design; disability; dopaminergic neuron; drug seeking behavior; executive function; experience; frontal lobe; improved; interest; men; motor control; neuromechanism; nicotine patch; nicotine replacement; non-smoking; premature; psychostimulant; public health relevance; relating to nervous system; response; sensor; smoking cessation; theories

DESCRIPTION (provided by applicant): The difficulty quitting and chronic relapse which characterize the experience of many smokers may be due in large measure to the adaptations in neural mechanisms regulating reward, affect, and goal- directed behavior that have taken place as a consequence of repeated drug use. Recent theoretical formulations of nicotine dependence have suggested that these motivational systems have been compromised in ways that bias the individual's cognitive resources and behavior towards smoking, even with the explicit goal to quit. Cognitive control in general and error monitoring specifically is critical to overcoming the potent neural mappings that drive smoking behavior under these conditions. The specific aims of this proposal are to study neural substrates related to error monitoring in a sample of smokers attempting to quit using behavioral counseling and the transdermal nicotine patch. This study will utilize electrophysiological (dense sensor array EEG recording) to measure the error-related negativity (ERN), an event-related potential likely generated in the anterior cingulate cortex (ACC) and related areas of the pre-frontal cortex that occurs following a response error. Studies suggest that the ERN directly reflects the activity of mesolimbic dopamine neurons, whose firing patterns activate/inhibit the ACC and encode events as events as being "worse" (making an error) or "better" (receiving a reward) than expected. Smokers interested in quitting will participate in two counterbalanced laboratory sessions (one deprived and one non-deprived) prior to their quit date in which they will complete a modified 2-choice flanker task. Each trial will be followed by feedback indicating whether the participant initiated a correct, incorrect, or late response. In half of the trials, correct trials will be followed by positively motivating images (pictures of erotic couples) and incorrect by neutral images (pictures of animals); in the other half, correct responses will be followed by neutral images (plants) and incorrect by negatively motivating images (mutilations). Smokers will enter smoking cessation therapy consisting of counseling and nicotine replacement following the second EEG assessment. The design will enable us to tease apart the relative impact of approach (reward) and avoidance motivation on the efficiency of the behavioral (error) monitoring system and its relation to abstinence. We predict that nicotine deprivation will alter the effects of the ERN: potentially increasing error monitoring on positive trials and/or decreasing error monitoring on negatively motivating trials. It is expected that individuals showing the smallest decrease in the ERN between either deprivation or motivational conditions will have higher abstinence rates at the end of treatment. The results of this study will improve our understanding of the neurobiological systems associated with reward, affect, and cognitive control among smokers by informing theory and potentially contributing to future interventions aimed at normalizing these systems during cessation. PUBLIC HEALTH RELEVANCE: The difficulty quitting and chronic relapse which characterize the experience of many smokers may be due in large measure to the adaptations in neural mechanisms regulating reward, affect, and goal-directed behavior that have taken place as a consequence of repeated drug use. This study will use the ERN (error related negativity) component of the ERP (event related potential) to determine the relative impact of approach (reward) and avoidance motivation on the efficiency of the behavioral (error) monitoring system and its relation to abstinence. We predict that nicotine deprivation will alter the effects of the ERN: potentially increasing error monitoring on positive trials and/or decreasing error monitoring on negatively motivating trials. It is expected that individuals showing the smallest decrease in the ERN between either deprivation or motivational conditions will have higher abstinence rates at the end of treatment. The results of this study will improve our understanding of the neurobiological systems associated with reward, affect, and cognitive control among smokers by informing theory and potentially contributing to future interventions aimed at normalizing these systems during cessation.

描述（由申请方提供）：戒烟困难和慢性复发是许多吸烟者经历的特征，这可能在很大程度上是由于调节奖励、情感和目标导向行为的神经机制的适应性改变，这些适应性改变是重复使用药物的结果。尼古丁依赖的最新理论公式表明，这些动机系统已经受到损害，使个人的认知资源和行为偏向吸烟，即使有明确的目标戒烟。一般的认知控制和具体的错误监控对于克服在这些条件下驱动吸烟行为的强有力的神经映射至关重要。本提案的具体目的是研究与错误监测相关的神经基质，以尝试使用行为咨询和尼古丁透皮贴剂戒烟的吸烟者为样本。本研究将利用电生理学（密集传感器阵列EEG记录）来测量错误相关负波（ERN），这是一种可能在前扣带皮层（ACC）和前额叶皮层相关区域中产生的事件相关电位，发生在反应错误之后。研究表明，ERN直接反映了中脑边缘多巴胺神经元的活动，其放电模式激活/抑制ACC并将事件编码为比预期“更糟”（犯错误）或“更好”（获得奖励）的事件。有兴趣戒烟的吸烟者将在戒烟日期之前参加两个平衡实验室会议（一个剥夺和一个非剥夺），他们将完成修改后的2选择侧翼任务。每次试验后将提供反馈，说明受试者是否启动了正确、不正确或延迟的应答。在一半的试验中，正确的试验之后是积极的激励图像（色情夫妇的照片），不正确的是中性图像（动物的照片）;在另一半，正确的反应之后是中性图像（植物），不正确的是消极的激励图像（肢解）。吸烟者将在第二次EEG评估后进入戒烟治疗，包括咨询和尼古丁替代。该设计将使我们能够梳理出接近（奖励）和回避动机对行为（错误）监测系统效率的相对影响及其与禁欲的关系。我们预测，尼古丁剥夺将改变ERN的影响：可能增加错误监测积极的试验和/或减少错误监测消极的激励试验。预计在剥夺或激励条件之间ERN下降最小的个体在治疗结束时将具有更高的戒断率。这项研究的结果将提高我们对吸烟者中与奖励，影响和认知控制相关的神经生物学系统的理解，为理论提供信息，并可能有助于未来的干预措施，旨在使这些系统在戒烟过程中正常化。公共卫生关系：戒烟困难和慢性复发是许多吸烟者经历的特征，这在很大程度上可能是由于调节奖励、情感和目标导向行为的神经机制的适应性改变，这些改变是重复使用药物的结果。本研究将使用ERP（事件相关电位）的ERN（错误相关负性）成分来确定接近（奖励）和回避动机对行为（错误）监测系统效率的相对影响及其与禁欲的关系。我们预测，尼古丁剥夺将改变ERN的影响：可能增加错误监测积极的试验和/或减少错误监测消极的激励试验。预计在剥夺或激励条件之间ERN下降最小的个体在治疗结束时将具有更高的戒断率。这项研究的结果将提高我们对吸烟者中与奖励，影响和认知控制相关的神经生物学系统的理解，为理论提供信息，并可能有助于未来的干预措施，旨在使这些系统在戒烟过程中正常化。