Nanoparticles for Noninvasive Thermometry Monitoring
用于无创测温监测的纳米颗粒
基本信息
- 批准号:7708597
- 负责人:
- 金额:$ 15.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-06 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:AblationAddressAmericanAnimal ModelAntineoplastic AgentsArrhythmiaCaringCause of DeathCellsCenters of Research ExcellenceContrast MediaDependenceDevicesDiagnosisDiagnosticDiffusionDrug Delivery SystemsEffectivenessEnsureEnvironmentFeverFiber OpticsFrequenciesGoalsHeatingHumanImageImaging technologyInterventionKnowledgeMagnetic Resonance ImagingMagnetismMalignant - descriptorMalignant NeoplasmsMapsMeasuresMedicalModalityMonitorMotionPatientsPharmaceutical PreparationsPredispositionProceduresProtonsProviderPublic HealthRelaxationResearchResearch Project GrantsSelf-control as a personality traitSignal TransductionSimulateSiteSystemTechniquesTemperatureTestingTherapeuticTherapeutic InterventionTherapeutic heat applicationThermometryTimeTissuesTreatment EfficacyVariantWorkbasecancer therapycold temperaturedesigngene therapyhyperthermia treatmentimage guided interventioninterestmagnetic fieldmeetingsmonitoring devicenanomagneticnanoparticlenon-invasive monitornovelnovel strategiesparticleprogramspromoterpublic health relevanceresearch studyskillstargeted deliverytumor
项目摘要
DESCRIPTION (provided by applicant): Procedures such as hyperthermia, treatment of cardiac arrhythmias and heat sensitive promoters in gene therapy require temperature change monitoring. Magnetic resonance imaging (MRI) thermometry overcomes problems associated with invasive temperature monitoring techniques such as thermocouples and fiber optics. In the current MRI thermometry the temperature variation is detected by measuring small changes in the proton resonant frequency, longitudinal relaxation time or apparent diffusion coefficient. However, these techniques have low temperature sensitivity and influenced by the local motion and magnetic susceptibility variation. This R21 application is directed to a noninvasive thermometry monitoring system for determining a temperature of tissue to which hyperthermia treatment is administered. The noninvasive thermometry monitoring system uses magnetic nanoparticles having a known magnetic moment profile that correlates with temperatures. In hyperthermia treatment, the noninvasive thermometry monitoring system may be used to determine whether the target tissue is being heated as desired and to what temperature the target tissue is being heated. We have developed magnetic nanoparticles that have been demonstrated as hyperthermia agent and anti-cancer drug targeted delivery agents. With the assessment of an applied magnetic field the same particles have also demonstrated the ability to prolong the delivery of its anti-cancer agent to tumors. However, a major technical challenge that has not been effectively met is the ability to monitor the effectiveness and progress of the hyperthermia treatment. The overall aim of this exploratory research application is to evaluate the feasibility of MRI-thermometry monitoring during hyperthermia therapy. The long-term goal of this research program is to integrate existing complementary modalities of diagnosis and therapy with safe multifunctional nanoparticles that will enable non-invasive monitoring and guiding of interventions without having to change the environment. The proposed exploratory research has two specific aims. The first specific aim is to evaluate the contrast ability of the hyperthermia magnetic nanoparticles in ex vivo with parameters that simulate patient testing conditions. The second specific aim is to develop thermometry (temperature contour) based on the MRI contrast imaging experiments. It is anticipated that upon the successful completion of this exploratory research project a subsequent project will be initiated to evaluate the MRI-guided magnetic hyperthermia therapy in an animal model.
PUBLIC HEALTH RELEVANCE: This exploratory research project evaluates the non-invasive thermometry ability of novel classes of magnetic nanoparticles that have potential to serve as agent for MRI-guided magnetic hyperthermia cancer therapy. The multifunctional magnetic nanoparticles have shown to be safe to human cells, able to elevate the temperature at the tumor site and able to selectively deliver drugs to tumors. Upon the successful completion of this project, it is anticipated that the use of the developed particles will provide a novel and site-specific monitoring of imaging guided intervention therapy.
描述(申请人提供):基因治疗中的热疗、心律失常治疗和热敏启动子等程序需要温度变化监测。磁共振成像(MRI)测温技术克服了与热电偶和光纤等侵入性温度监测技术相关的问题。在目前的磁共振测温中,温度变化是通过测量质子共振频率、纵向弛豫时间或表观扩散系数的微小变化来检测的。然而,这些技术的温度敏感性较低,且受局部运动和磁化率变化的影响。本R21申请涉及用于确定对其实施热疗的组织的温度的非侵入性测温监控系统。非侵入性体温监测系统使用具有已知磁矩分布的磁性纳米粒子,该磁矩分布与温度相关。在热疗中,非侵入性测温监控系统可用于确定目标组织是否如所需地被加热以及目标组织被加热到什么温度。我们已经开发出磁性纳米颗粒,已经被证明是热疗剂和抗癌药物靶向递送剂。通过对外加磁场的评估,相同的颗粒也证明了延长其抗癌药物对肿瘤的输送的能力。然而,尚未有效应对的一个主要技术挑战是监测热疗治疗的有效性和进展的能力。这一探索性研究应用的总体目的是评估在热疗过程中应用MRI测温监测的可行性。这项研究计划的长期目标是将现有的互补诊断和治疗方式与安全的多功能纳米颗粒相结合,从而在不必改变环境的情况下实现对干预措施的非侵入性监测和指导。拟议的探索性研究有两个具体目标。第一个具体目标是用模拟患者测试条件的参数来评估热疗磁性纳米颗粒在体外的对比能力。第二个具体目标是开发基于MRI对比成像实验的温度测量(温度等值线)。预计在这一探索性研究项目成功完成后,将启动一个后续项目,在动物模型中评估MRI引导的磁热疗法。
与公共健康相关:这项探索性研究项目评估了新型磁性纳米颗粒的非侵入性测温能力,这些纳米颗粒有可能作为MRI引导的磁热疗癌症治疗的试剂。多功能磁性纳米颗粒已被证明对人类细胞安全,能够提高肿瘤部位的温度,并能够选择性地将药物输送到肿瘤。在该项目成功完成后,预计所开发的颗粒的使用将为成像引导的介入治疗提供一种新颖的、特定于部位的监测。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Yousef Haik其他文献
Yousef Haik的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
African American (AA) Communities Speak: Partnering with AAs in the North and South to Train Palliative Care Clinicians to Address Interpersonal and Systemic Racism and Provide Culturally Aligned Care
非裔美国人 (AA) 社区发言:与北部和南部的 AA 合作,培训姑息治疗临床医生,以解决人际和系统性种族主义并提供文化一致的护理
- 批准号:
10734272 - 财政年份:2023
- 资助金额:
$ 15.35万 - 项目类别:
GODDESS (Gathering Online for Dialogue and Discussion to Enhance Social Support): Engaging young African American women in a virtual group app to address alcohol misuse, sexual risk, and PrEP in NC
GODDESS(在线聚集进行对话和讨论,以加强社会支持):让年轻的非裔美国女性参与虚拟团体应用程序,以解决北卡罗来纳州的酒精滥用、性风险和 PrEP 问题
- 批准号:
10541028 - 财政年份:2022
- 资助金额:
$ 15.35万 - 项目类别:
GODDESS (Gathering Online for Dialogue and Discussion to Enhance Social Support): Engaging young African American women in a virtual group app to address alcohol misuse, sexual risk, and PrEP in NC
GODDESS(在线聚集进行对话和讨论,以加强社会支持):让年轻的非裔美国女性参与虚拟团体应用程序,以解决北卡罗来纳州的酒精滥用、性风险和 PrEP 问题
- 批准号:
10684239 - 财政年份:2022
- 资助金额:
$ 15.35万 - 项目类别:
A multidimensional Digital Approach to Address Vaccine Hesitancy and Increase COVID-19 Vaccine Uptake among African American Young Adults in the South
解决疫苗犹豫问题并提高南方非裔美国年轻人对 COVID-19 疫苗接种率的多维数字方法
- 批准号:
10395616 - 财政年份:2021
- 资助金额:
$ 15.35万 - 项目类别:
A multidimensional Digital Approach to Address Vaccine Hesitancy and Increase COVID-19 Vaccine Uptake among African American Young Adults in the South
解决疫苗犹豫问题并提高南方非裔美国年轻人对 COVID-19 疫苗接种率的多维数字方法
- 批准号:
10786490 - 财政年份:2021
- 资助金额:
$ 15.35万 - 项目类别:
Reducing Hypertension among African American Men: A Mobile Stress Management Intervention to Address Health Disparities
减少非裔美国男性的高血压:解决健康差异的移动压力管理干预措施
- 批准号:
10821849 - 财政年份:2021
- 资助金额:
$ 15.35万 - 项目类别:
Reducing Hypertension among African American Men: A Mobile Stress Management Intervention to Address Health Disparities
减少非裔美国男性的高血压:解决健康差异的移动压力管理干预措施
- 批准号:
10384110 - 财政年份:2021
- 资助金额:
$ 15.35万 - 项目类别:
A multidimensional Digital Approach to Address Vaccine Hesitancy and Increase COVID-19 Vaccine Uptake among African American Young Adults in the South
解决疫苗犹豫问题并提高南方非裔美国年轻人对 COVID-19 疫苗接种率的多维数字方法
- 批准号:
10336591 - 财政年份:2021
- 资助金额:
$ 15.35万 - 项目类别:
Community-Academic Partnerships to Address COVID-19 Inequities within African American Communities
社区学术伙伴关系解决非裔美国人社区内的 COVID-19 不平等问题
- 批准号:
10245326 - 财政年份:2021
- 资助金额:
$ 15.35万 - 项目类别:
Engaging scientists and communities to address the impacts of substance abuse on American Indian and Alaska Native children and families: The Native Children's Research Exchange Annual Meetings
让科学家和社区参与解决药物滥用对美洲印第安人和阿拉斯加原住民儿童和家庭的影响:原住民儿童研究交流年会
- 批准号:
10657317 - 财政年份:2020
- 资助金额:
$ 15.35万 - 项目类别: