Microevolution and transmission of MRSA in a hospital setting

MRSA 在医院环境中的微进化和传播

• 批准号: nhmrc : 1010452
• 负责人: Dr Matthew O'Sullivan
• 金额: $ 41.56万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microevolution-transmission-mrsa-hospital-setting/109494
• 关键词: Microevolution; transmission; MRSA; hospital; setting

Multi-drug resistant Staphylococcus aureus (MRSA) cause hospital-acquired infections and are responsible for unnecessary illness and excess health costs. It is hard to identify how different strains spread and which are most likely to cause disease, without a rapid, simple fingerprinting system. We have developed one, which we will use to identify the most _successful� MRSA strains. Then we will sequence their whole genomes, to determine why they are _successful� to devise ways to combat them.

耐多药金黄色葡萄球菌（MRSA）引起医院获得性感染，并造成不必要的疾病和额外的卫生费用。如果没有一个快速、简单的指纹识别系统，很难确定不同的菌株是如何传播的，以及哪些最有可能导致疾病。我们已经开发了一个，我们将用它来识别最成功的MRSA菌株。然后，我们将对它们的整个基因组进行测序，以确定它们“成功”的原因，从而设计出对抗它们的方法。