The true burden of nosocomial staphylococcal disease: Genomic markers of transmission of methicillin-sensitive and –resistant Staphylococcus aureus

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Staphylococcus aureus is the leading cause of hospital infection, but previous studies have only focused on the 30% caused by resistant strains (MRSA). We will trace the spread of all Staphylococcus strains in hospitals using DNA fingerprinting. This will enable us to determine why patients catch this infection, permitting interventions to reduce hospital infection. We will also examine the genomes of these bacteria to look for markers of transmission and adaptation to the hospital environment.