Cerebrovascular Contributions to Brain Aging and Dementia

脑血管对大脑衰老和痴呆的影响

• 批准号: 7503987
• 负责人: DAVID H SALAT
• 金额: $ 42.92万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-29 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7503987
• 关键词: Adult; Affect; Alzheimer' s Disease; American; Atrophic; Attenuated; Autopsy; Blood Vessels; Brain; Cause of Death; Cerebrovascular Disorders; Clinical; Clinical Trials; Clinical assessments; Cognition; Cognitive; Complex; Condition; Data; Dementia; Development; Diagnosis; Diffusion Magnetic Resonance Imaging; Elderly; Episodic memory; Evaluation; Event; Goals; Gray unit of radiation dose; Health; Image; Impaired cognition; Individual; Inferior; Intervention; Knowledge; Lifestyle Therapy; Magnetic Resonance Imaging; Masks; Measures; Medial; Memory; Methods; Modeling; Modification; Monitor; Nerve Degeneration; Participant; Pathology; Patients; Performance; Physiological; Procedures; Process; Rate; Research Personnel; Risk; Short-Term Memory; Stroke; Survival Analysis; Syndrome; Testing; Therapeutic; Therapeutic Intervention; Thick; Time; Tissues; Work; age related; aging brain; cerebral atrophy; cerebrovascular; cognitive control; diffusion anisotropy; disorder risk; executive function; follow-up; frontal lobe; gray matter; indexing; long term memory; mild neurocognitive impairment; neuroimaging; novel; programs; relating to nervous system; white matter

DESCRIPTION (provided by applicant): Cerebrovascular contributions to brain aging and dementia. Cerebrovascular disease (CVD) contributes in a complex manner to a host of detrimental age-related conditions including cognitive decline, neurodegeneration, and the clinical syndrome of Alzheimer's disease (AD). Still, little is known about how CVD affects the brain and cognition in these conditions. The goal of this proposal is to define the cognitive and neural consequences of CVD, and how CVD-related changes alter the course of clinical decline in AD through the use of a host of novel, advanced neuroimaging procedures. Aim 1. To identify the contribution of CVD to brain gray (GM) and white matter (WM) degeneration in older adults and in patients with AD. Hypothesis 1. Poor Cerebrovascular health contributes to GM and WM degeneration in the frontal lobe. High stroke risk at baseline predicts subsequent tissue degeneration at follow up assessment. Aim 2. To determine how CVD associated brain changes contribute to cognitive decline. Hypothesis 2. A relation exists between CVD and cognitive decline with strong associations between stroke risk and working memory, as opposed to long term memory. Aim 3. To understand how CVD contributes to clinical status, brain aging, and the progression to AD. Hypothesis 3. CVD is related to changes in cognition across time with most pronounced relations between stroke risk and reduced working, as opposed to long term, memory abilities. CVD related WM degeneration is a risk for the development of dementia. CVD risk will be characterized using the Framingham Stroke Risk profile which integrates clinical and quantitative physiological data. We will model the association between CVD measures and MRI measures of with a focus on how stroke risk predicts subsequent neural degeneration and clinical decline. Measures of CVD will be related to change in cognitive abilities and imaging measures across testing sessions separated by two and four years to determine whether CVD or associated brain changes affect the rate of the conversion from mild cognitive impairment to dementia. Knowledge from the proposed studies would be useful in the differential therapeutic intervention of AD and CVD related brain degeneration.

描述（由申请人提供）：脑血管对脑老化和痴呆的贡献。脑血管疾病（CVD）以复杂的方式导致许多有害的年龄相关疾病，包括认知能力下降、神经退行性变和阿尔茨海默病（AD）的临床综合征。尽管如此，人们对CVD如何在这些条件下影响大脑和认知知之甚少。该提案的目标是定义CVD的认知和神经后果，以及CVD相关变化如何通过使用大量新颖的先进神经影像学程序改变AD临床下降的过程。目标1.确定CVD对老年人和AD患者脑灰质（GM）和白色质（WM）变性的影响。假设1.脑血管健康状况不佳会导致额叶的GM和WM退化。基线时卒中风险高预示后续随访评估时组织变性。目标2.确定CVD相关的大脑变化如何导致认知能力下降。假设2.心血管疾病和认知能力下降之间存在联系，中风风险和工作记忆之间存在很强的联系，而不是长期记忆。目标3.了解CVD如何影响临床状态、脑老化和AD进展。假设3. CVD与认知随时间的变化有关，中风风险与工作减少之间的关系最明显，而不是长期记忆能力。CVD相关的WM变性是痴呆发展的风险。CVD风险将使用融合临床和定量生理数据的卒中风险特征进行表征。我们将模拟CVD测量和MRI测量之间的关联，重点是卒中风险如何预测随后的神经退行性变和临床衰退。CVD的测量将与间隔两年和四年的测试期间的认知能力和成像测量的变化相关，以确定CVD或相关的大脑变化是否影响从轻度认知障碍到痴呆的转化率。从拟议的研究中获得的知识将有助于AD和CVD相关脑变性的差异化治疗干预。