Genetic and environmental factors in cancer

这个项目包括两项肺癌研究和我与NIEHS姐妹研究的合作。第一个是洛杉矶的非裔美国人和白种人对肺癌遗传易感性的病例对照研究。我在南加州大学担任教职时进行了这项研究。在这项研究中，我检测了大量与肺癌相关的基因多态性。我正在与我以前在南加州大学的学生合作，对异硫氰酸酯、GSTM1多态性和肺癌风险进行分析，这是我在上海的研究发现的后续研究。我们也在合作分析抗hu抗体与小细胞肺癌的关系。

This project includes two lung cancer studies and my work with the NIEHS sister study. The first is a case-control study of genetic susceptibility to lung cancer in African-Americans and Caucasians in Los Angeles. I conducted this study while a faculty member at the University of Southern California. I have examined a large number of genetic polymorphisms relevant to lung cancer in this study. I am collaborating with my former student from USC on an analysis of isothiocyanates, GSTM1 polymorphisms and lung cancer risk, a follow-up of my Shanghai study finding. We are also collaboration on an analysis of anti-Hu antibody in the relation to small cell lung cancer. A second study is a pooling project where I have contributed my lung cancer data to a collaborative study to pool across a number of lung cancer studies to provide sufficient power for studying gene-environment interactions. I serve on the advisory committee for this pooling project. In other breast cancer research, I am also a collaborator on the Sister Study having been involved in the initial concept. I am a collaborator with a team led by Dr. Clarice Weinberg to add sample and exposure data collection on sisters with early onset breast cancer of participants in the cohort. This study uses a novel quad design. Dr. Weinberg received external funding for this project from the Komen foundation.