MAGNETIC FIELDS AND BREAST CANCER RISK

暴露在磁场中会增加乳腺癌的假说 风险是基于与乳腺癌的高发病率的一致性 随着工业化的出现，一种看似合理的生物机制和一些 有限的男性流行病学数据。然而，女性的数据很少，而且 自相矛盾。 我们建议一项嵌套在预期队列中的病例对照研究。 洛杉矶县的非裔美国人和拉丁裔妇女。初级阶段 具体目标是解决乳腺癌风险是否增加 更高的暴露在磁场中，通过以下评估： (1)占用至少6户的所有住宅的布线配置编码 与过去10年相比， (2)7以上交流电磁场的测量 天，包括6天在卧室里测量的电流 住处和1天的个人监控。 次要的特定目标是检验特定的假设 交流磁场和直流(DC)磁场的组合 野战会增加患乳腺癌的风险。 我们将招募731名确诊为乳腺癌4.5岁以上的女性 年和731名对照，从队列中随机抽样。除了……之外 现场测量，我们将管理一份关于住宅和 职业性暴露于磁场和光照的来源 在晚上，一个潜在的混血儿。 嵌套式病例对照研究设计将选择偏倚降至最低 关于导线配置编码，存在严重的潜在问题 住宅暴露在磁场中与癌症风险的研究。在……里面 此外，与以前相比，使用了更广泛的测量 对磁场和癌症风险的研究将改善对 曝光。

The hypothesis that exposure to magnetic fields increases breast cancer risk is based on consistency with the high rates of breast cancer occurring with industrialization, a plausible biologic mechanism and some limited epidemiologic data in men. However, data in women are few and contradictory. We propose a case-control study nested within a prospective cohort of African-American and Latino women in Los Angeles County. The primary specific aim is to address whether breast cancer risk is increased by higher exposure to magnetic fields as assessed by: (1) wiring configuration coding of all homes occupied for at least 6 months over the previous 10 years and (2) measurements of the alternating current (AC) magnetic field over 7 days, including 6 days of measurements in the bedroom of the current residence and 1 day of personal monitoring. A secondary specific aim is to test the hypothesis that particular combinations of the AC magnetic field and the direct current (DC) magnetic field increase the risk of breast cancer. We will enroll 731 women with incident breast cancer diagnosed over 4.5 years and 731 controls, randomly sampled from the cohort. In addition to field measurements, we will administer a questionnaire on residential and occupational sources of exposure to magnetic fields and exposure to light at night, a potential confounder. The nested case-control study design will minimize selection bias with respect to wire configuration coding, a serious potential problem in studies of residential exposure to magnetic fields and cancer risk. In addition, the use of more extensive measurements compared with previous studies of magnetic fields and cancer risk will improve assessment of exposure.