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Novel Use of fMRI to Study Substance Abuse Problems

功能磁共振成像研究药物滥用问题的新用途

基本信息

批准号：
7600619
负责人：
LISA D NICKERSON
金额：
$ 14.23万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-04-01 至 2010-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7600619
关键词：
Acute Adolescent Adult Affect Age Agreement Alcohol dependence Area Behavior Brain Brain imaging Cannabis Cardiovascular system Cerebrum Cognitive Communities Complement Cues Data Data Analyses Development Drug Kinetics Drug abuse Drug usage Effectiveness Equilibrium Equipment Euphoria Event Exhibits Experimental Designs Female Functional Magnetic Resonance Imaging Funding Galvanic Skin Response Growth Heart Rate Hospitals Human Image Imaging Techniques Intake Investigation K-Series Research Career Programs Laboratories Left Life Light Manuscripts Marijuana Marijuana Smoking Measurable Measurement Measures Mentors Methods Modality Nature Neurosciences Oral Patient Self-Report Pattern Performance Pharmaceutical Preparations Physiological Physiology Population Positron-Emission Tomography Property Publishing Relapse Reporting Research Research Design Research Personnel Research Project Grants Research Training Resolution Scientist Signal Transduction Skin Temperature Smoking Statistical Data Interpretation Statistical Methods Stimulus Substance abuse problem Task Performances Techniques Testing Time Training Visit Visual aged alcohol cue alcohol response base blood oxygenation level dependent response brain size craving critical developmental period cue reactivity early adolescence emerging adult experience flexibility gray matter hemodynamics human subject imaging modality in vivo insight intravenous administration marijuana user meetings neuroimaging novel programs response social white matter

项目摘要

DESCRIPTION (provided by applicant): This is a request for five years of funding through the K25 Quantitative Mentored Research Career Development Award mechanism. The candidate, an imaging physicist and statistician, has proposed an intensive training and research program to facilitate her growth as an interdisciplinary scientist, capable of obtaining support for the development of newly emerging functional magnetic resonance imaging (fMRI) techniques to study substance abuse problems. The training plan reflects a combination of coursework, laboratory visits, and meetings to provide formal training in the areas of neuroscience and substance abuse that will both complement the experience of and expedite the successful completion of the research projects. The use of fMRI to study drug abuse problems is still relatively uncommon, but in general, holds great promise for this application, fMRI methods - both study designs and data/statistical analyses - are still evolving at a very rapid pace; this can be an incredible obstacle for investigators who wish to utilize fMRI but do not have the imaging background to select an appropriate study design. The research plan focuses on the optimization of novel fMRI techniques to study aspects of marijuana use in adolescents and adults and on the dissemination of these lesser known, yet incredibly flexible, methods to the substance abuse research community. The first project investigates differences in reactivity to visual, audio, and olfactory drug cues between adolescents and adults who use marijuana. Subjective responses (self-reports of cue-induced marijuana craving) and physiological responses (skin temperature, heart rate, and skin conductance) will be recorded and analyzed using multivariate statistical methods. Responses for both groups will also be compared with responses from healthy matched control subjects. The second project is an event-related fMRI study of the effects of cue induced craving on performance of an oddball task in adolescent and adult marijuana users (healthy matched control subjects will also be tested). The study design and data analysis strategy will permit the assessment of two different aspects of craving, each over a different time scale. The third project is a pharmacological fMRI (phMRI) study that will tackle the question of how acute administration of marijuana effects brain activity in adult marijuana users. The phMRI methods will be optimized to balance the impact of the unwieldy pharmacokinetic properties of marijuana and the small and temporally variable cognitive effects. All together, these three projects will constitute an invaluable training experience for the candidate while demonstrating the versatility of newer fMRI techniques in studying substance abuse problems and providing a better understanding of marijuana effects in adolescents and adults.

描述（由申请人提供）：这是通过 K25 定量指导研究职业发展奖机制提供五年资助的请求。该候选人是一名成像物理学家和统计学家，她提出了一项强化培训和研究计划，以促进她成长为一名跨学科科学家，能够为开发新兴的功能磁共振成像（fMRI）技术来研究药物滥用问题获得支持。该培训计划结合了课程作业、实验室参观和会议，以提供神经科学和药物滥用领域的正式培训，这既可以补充研究项目的经验，又可以加快研究项目的成功完成。使用功能磁共振成像来研究药物滥用问题仍然相对不常见，但总的来说，这种应用前景广阔，功能磁共振成像方法（研究设计和数据/统计分析）仍在以非常快的速度发展；对于希望利用功能磁共振成像但没有成像背景来选择合适的研究设计的研究人员来说，这可能是一个令人难以置信的障碍。该研究计划的重点是优化新型功能磁共振成像技术，以研究青少年和成人大麻使用的各个方面，并将这些鲜为人知但非常灵活的方法传播给药物滥用研究界。第一个项目调查吸食大麻的青少年和成年人对视觉、听觉和嗅觉药物线索的反应差异。主观反应（提示诱发的大麻渴望的自我报告）和生理反应（皮肤温度、心率和皮肤电导）将使用多元统计方法进行记录和分析。两组的反应也将与健康匹配的对照受试者的反应进行比较。第二个项目是一项与事件相关的功能磁共振成像研究，研究提示引起的渴望对青少年和成年大麻使用者执行奇怪任务的影响（还将测试健康匹配的对照受试者）。研究设计和数据分析策略将允许评估渴望的两个不同方面，每个方面都在不同的时间范围内。第三个项目是药理学功能磁共振成像（phMRI）研究，该研究将解决急性吸食大麻如何影响成年大麻使用者的大脑活动的问题。 phMRI 方法将进行优化，以平衡大麻笨重的药代动力学特性和微小且随时间变化的认知效应的影响。总之，这三个项目将为候选人提供宝贵的培训经验，同时展示新的功能磁共振成像技术在研究药物滥用问题和更好地了解大麻对青少年和成人的影响方面的多功能性。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

DOI：
10.1016/j.neuroimage.2011.11.063
发表时间：
2012-02-15
期刊：
NEUROIMAGE
影响因子：
5.7
作者：
Filippini, N.;Nickerson, L. D.;Beckmann, C. F.;Ebmeier, K. P.;Frisoni, G. B.;Matthews, P. M.;Smith, S. M.;Mackay, C. E.
通讯作者：
Mackay, C. E.

Using Dual Regression to Investigate Network Shape and Amplitude in Functional Connectivity Analyses.