NYU WORLD TRADE CENTER RESPONDER HEALTH CONSORTIUM PROTOCOL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一个由NIH/NIOSH资助的多中心项目。它包括对世界贸易中心(WTC)反应人员和志愿者进行纵向筛选和监测。中央数据协调中心位于Mt.西奈医院。纽约大学的人口将包括纽约警察局和临时工以及金属行业的工人，他们将每18个月进行一次登记和筛查(问卷调查、考试、肺功能测试)。假设WTC暴露后出现新的呼吸道症状，表现为小气道功能障碍或呼吸道高反应性。这项研究将检查新发哮喘样症状的患者。评估将包括1)肺功能测试(肺活量、体积描记、乙酰甲胆碱激发)；2)炎症生物标志物(呼气)；以及吸入皮质类固醇的效果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an NIH/NIOSH-funded multicenter program. It consists of a longitudinal screening and surveillance of World Trade Center (WTC) responders and volunteers. The Central Data Coordinating Center is at Mt. Sinai Hospital. The NYU population will consist of NYPD and day laborers and workers in the metal trades, who will be enrolled and screened every 18 months (questionnaire, exam, pulmonary function tests). The hypothesis is that WTC exposure with new-onset respiratory symptoms manifests as small airway dysfunction or airway hyperresponsiveness. The study will examine patients with new-onset asthma-like symptoms. Assessments will include 1) Pulmonary function tests (spirometry, plethysmography, methacholine challenge; 2) biomarkers of inflammation (exhaled breath); and effects of inhaled corticosteroid.