NYU WORLD TRADE CENTER RESPONDER HEALTH CONSORTIUM PROTOCOL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一个由NIH/NIOSH资助的多中心项目。 它包括对世界贸易中心（WTC）应急人员和志愿者的纵向筛查和监测。 中央数据协调中心位于Mt。西奈医院。 纽约大学的人口将包括纽约市警察局和金属行业的日工和工人，他们将每18个月进行一次登记和筛查（问卷调查、检查、肺功能测试）。 假设暴露于WTC并出现新发呼吸道症状表现为小气道功能障碍或气道高反应性。 这项研究将检查新发哮喘样症状的患者。 评估将包括1）肺功能检查（肺量测定法、体积描记法、乙酰甲胆碱激发; 2）炎症生物标志物（呼出气）;以及吸入皮质类固醇的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an NIH/NIOSH-funded multicenter program. It consists of a longitudinal screening and surveillance of World Trade Center (WTC) responders and volunteers. The Central Data Coordinating Center is at Mt. Sinai Hospital. The NYU population will consist of NYPD and day laborers and workers in the metal trades, who will be enrolled and screened every 18 months (questionnaire, exam, pulmonary function tests). The hypothesis is that WTC exposure with new-onset respiratory symptoms manifests as small airway dysfunction or airway hyperresponsiveness. The study will examine patients with new-onset asthma-like symptoms. Assessments will include 1) Pulmonary function tests (spirometry, plethysmography, methacholine challenge; 2) biomarkers of inflammation (exhaled breath); and effects of inhaled corticosteroid.