NYU WORLD TRADE CENTER RESPONDER HEALTH CONSORTIUM PROTOCOL

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an NIH/NIOSH-funded multicenter program. It consists of a longitudinal screening and surveillance of World Trade Center (WTC) responders and volunteers. The Central Data Coordinating Center is at Mt. Sinai Hospital. The NYU population will consist of NYPD and day laborers and workers in the metal trades, who will be enrolled and screened every 18 months (questionnaire, exam, pulmonary function tests). The hypothesis is that WTC exposure with new-onset respiratory symptoms manifests as small airway dysfunction or airway hyperresponsiveness. The study will examine patients with new-onset asthma-like symptoms. Assessments will include 1) Pulmonary function tests (spirometry, plethysmography, methacholine challenge; 2) biomarkers of inflammation (exhaled breath); and effects of inhaled corticosteroid.