A FUNCTIONAL MRI STUDY OF MOTHER-INFANT ATTACHMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 假设 通过测量母亲/父亲对婴儿面部线索的功能性MRI反应，确定父母-婴儿依恋的功能性神经解剖学相关因素。 嗨，我是说与不安全的母婴配对相比，安全自主的母亲在面对自己的婴儿时，右眶额皮层的fMRI激活明显高于面对陌生婴儿的fMRI激活。 其他有显著差异的区域包括丘脑核（奖赏区）、杏仁核和海马（应激反应）以及终纹床核（催产素通路）。 通过测定血清催产素、皮质醇和儿茶酚胺水平，探讨安全型母亲与不安全型母亲在婴儿相关应激反应中的差异。 H2：在镜像互动情境的静止面孔压力源之后，安全自主母亲的催产素水平将从基线上升，但在不安全连接的母亲中保持不变或下降。 H2：与安全的母亲相比，不安全的母亲将表现出基础皮质醇升高，并表现出对婴儿相关应激源的夸大的儿茶酚胺反应。 使用镜像互动情境来确定依恋组在其他婴儿反应中的差异。 H3：昆虫分类的母亲将表现出较少的应急面部反应，他们的婴儿在镜子互动情境和关怀指数。 H3：不安全依恋的婴儿（特别是无组织的婴儿）将表现出对完全偶然的自我刺激（即他们自己的形象）的偏好，而不是他们的母亲在镜子互动情境中的形象。 确定母亲和婴儿依恋分类之间的相关程度。 安全自主的母亲依恋分类，使用成人依恋访谈，和安全的婴儿分类六个月后，使用奇怪的情况程序之间存在显着相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESIS To identify functional neuroanatomical ocrrelates of parent-infant attachemnt, measuring maternal/paternal functional MRI responses to infant facial cues. HI: Compared with insecure mother-infant dyads, secure-autonomous mothers will demonstrate significantly more fMRI activation of the right orbitofrontal cortex when exposed to their own infant vs. unknown infant facial imates. Other areas of significant difference will include the nucleus accumbens (reward area), amygdala and hippocampus (stress responses) and bed nucleus of the striae terminales (oxytocin pathways). To idently differences in secure vs. insecure mothers' infant-related stress responses, measuring sequential serum oxytocin, cortisol and catecholamines levels. H2: Following the still-face stressor of the Mirror Interaction Situation, ocytocin levels will rise from baseline in secure-autonomous mothers, but remain unchanged or decrease in insecurely attached mothers. H2: Insecure-classified mothers will demonstrate an elevated basal cortisol, and show an exaggerated catecholamine response to the infant-related stressor, compared to secure mothers. To determine differences between attachment groups in other-infant responses using the Mirror Interaction Situation. H3: Insecure-classified mothers will demonstrate fewer contingent facial responses to their infant during the Mirror Interaction Situaiton and CARE-Index. H3: Insecurely attached infants (particularly disorganized infants) will demonstrate a preference for perfectly contingent self-stimulation (i.e. their own image) over their mother's image in the Mirrow Interaction Situation. To determine the degree of correlation between maternal and infant attachment classifications. There will be a significant correlation between secure autonomous maternal attachment classification, using the Adult Attachment Interview, and secure infant classification six months later, using the Strange Situation procedure.