BRAIN MANGANESE DEPOSITION IN HIGH RISK NEONATES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 我们的研究旨在验证T1加权MR强度接受PN的新生儿基底神经节中的Mn（脑沉积的标志物）将与（1）总（胃肠外和肠内）膳食Mn摄入量，（2）PN总天数，（3）血锰水平（通过高分辨率电感耦合等离子体质谱法（HR-ICP-MS）测量）和（4）肝功能障碍和胆汁淤积的程度（通过结合胆红素水平评估）。我们进一步假设T1加权MR强度与（1）胎龄和（2）铁（Fe）状态（通过血清Fe、转铁蛋白、铁蛋白、总铁结合力和血红蛋白评估）呈负相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our studies are designed to test the hypotheses that T1-weighted MR intensities (a marker of Mn brain deposition) in the basal ganglia of neonates receiving PN will correlate directly with (1) total (parenteral and enteral) dietary Mn intake, (2) total days on PN, (3) blood Mn levels (measured by High Resolution Inductively Coupled Plasma-Mass Spectrometry (HR-ICP-MS)) and (4) degree of hepatic dysfunction and cholestasis (assessed by conjugated bilirubin levels). We further hypothesize that T1-weighted MR intensities will correlate inversely with (1) gestational age and (2) iron (Fe) status (assessed by serum Fe, transferrin, ferritin, total iron binding capacity and hemoglobin).