BRAIN MANGANESE DEPOSITION IN HIGH RISK NEONATES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的研究旨在检验如下假设：接受PN的新生儿基底节的T1加权MR强度(脑锰沉积的标志)将与(1)总的(肠外和肠内)饮食中的锰摄入量，(2)肠外营养的总天数，(3)血中的锰水平(用高分辨率电感耦合等离子体质谱(HR-ICPMS)测量)和(4)肝功能障碍和胆汁淤积的程度(用结合胆红素水平评估)直接相关。我们进一步假设，T1加权MR强度将与(1)胎龄和(2)铁(Fe)状态(通过血清铁、转铁蛋白、铁蛋白、总铁结合能力和血红蛋白评估)呈负相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our studies are designed to test the hypotheses that T1-weighted MR intensities (a marker of Mn brain deposition) in the basal ganglia of neonates receiving PN will correlate directly with (1) total (parenteral and enteral) dietary Mn intake, (2) total days on PN, (3) blood Mn levels (measured by High Resolution Inductively Coupled Plasma-Mass Spectrometry (HR-ICP-MS)) and (4) degree of hepatic dysfunction and cholestasis (assessed by conjugated bilirubin levels). We further hypothesize that T1-weighted MR intensities will correlate inversely with (1) gestational age and (2) iron (Fe) status (assessed by serum Fe, transferrin, ferritin, total iron binding capacity and hemoglobin).