Developmental Impact of NICU Exposures (DINE) phase II

NICU 暴露 (DINE) 第二阶段的发育影响

• 批准号: 10745062
• 负责人: Judy Lynn Aschner
• 金额: $ 128.18万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745062
• 关键词: Abate; Address; Adolescent; Age; Air Pollution; Area; Biological Specimen Banks; Birth; Bronchopulmonary Dysplasia; Caring; Chemical Exposure; Child; Child Development; Child Health; Child health care; Childhood Asthma; Clinical; Clinical Research; Consent; Data; Data Element; Data Set; Dedications; Dermal; Development; Endocrine Disruptors; Enrollment; Environmental Exposure; Exposure to; Face; Family; Funding; General Population; Goals; Health; Health Care Costs; High Prevalence; Hospitalization; Infant; Infrastructure; Inhalation; Intravenous; Investigation; Life; Life Cycle Stages; Link; Longterm Follow-up; Lung; Neonatal Intensive Care Units; Outcome; Participant; Pediatric cohort; Persons; Phase; Phenotype; Population; Pregnancy; Pregnant Women; Premature Birth; Premature Infant; Procedures; Protocols documentation; Research; Risk; Site; Third Pregnancy Trimester; United States; Visit; Work; adverse outcome; cohort; early childhood; early life exposure; experience; fetal; infancy; insight; interest; middle childhood; novel; participant enrollment; participant retention; pediatric health outcomes; phthalates; programs; pulmonary function; societal costs

Project Summary/Abstract The Environmental Influences on Child Health Outcomes (ECHO) program capitalizes on diverse pregnancy and pediatric cohorts to investigate the impact of a broad array of environmental influences on child health and development. Since 2016, the Developmental Impact of NICU Exposures (DINE) study has significant contribution of the to the ECHO mandate is a large, exquisitely phenotyped preterm birth cohort - a unique and sensitive population with a demonstrated large burden of adverse health outcomes. The DINE cohort readily combines rich existing clinical and research datasets and biospecimen repositories, existing infrastructure for long-term follow up and assessments of multiple ECHO exposure and outcome specialization areas, and a novel exposure and outcome profile that will continue high-yield contribution to ECHO program scientific goals. In this second phase of the ECHO program, we will continue to focus on the scientific premise that early life physical and chemical exposures, notably phthalates and air pollution, have long-lasting harmful effects on child health and development, and that these harmful effects are magnified in children born preterm. DINE contributes a unique and critically important population to ECHO in that preterm infants face significant dermal, inhalational and intravenous exposures to phthalates, ubiquitous organic endocrine disrupting chemicals, while hospitalized the neonatal intensive care unit (NICU). Premature infants experience a high prevalence of the adverse health effects that are associated with early life exposure to phthalates in term-born children, particularly abnormalities of pulmonary function. The contribution of environmental influences on adverse outcomes of preterm children is poorly understood. One additional central tenet of our work is that preterm infants can be studied to identify exposure-outcome links that may be more subtle in the general population. Large clinical studies like ECHO that enroll participants born over the entire preterm-to-term continuum allow rigorously study of this premise. Through the next phase of the ECHO program, we pursue the following Specific Aims in DINE: Aim 1. Leverage ECHO Cohort Protocol core data elements to compare exposure-outcome relationships in preterm compared to term populations. Aim 2. Leverage specialized data elements to address critical questions about the impact of early life chemical exposures on pulmonary development in a sensitive population, preterm infants. Aim 3. Implement procedures to maximize retention of existing participants with an emphasis on maintaining cohort diversity and protocol fidelity. Continued involvement of preterm infants in ECHO is critical not only to our cohort’s scientific imperatives, but also to the entire ECHO program as preterm infants constitute more than 10% of the United States population.

项目摘要/摘要 环境对儿童健康成果（ECHO）计划的影响将利用潜水的怀孕和 儿科人群调查各种环境影响对儿童健康的影响 发展。自2016年以来，NICU暴露（DINE）研究的发展影响很大 对回声授权的贡献是一个大型的，完全表现为早产群体 - 一个独特的和 敏感人群显示出大量不良健康结果。用餐队列很容易 结合了现有的现有临床和研究数据集以及生物传感存储库，现有的基础设施 长期随访和评估多个回声暴露和结果专业领域，以及一个新颖的 暴露和结果概况将继续对Echo计划科学目标的高收益贡献。 在回声计划的第二阶段，我们将继续关注早期的科学前提 物理和化学暴露，尤其是邻苯二甲酸盐和空气污染，对儿童具有长期有害影响 健康和发展，这些有害影响在生育的儿童中被放大。用餐有贡献 一个独特且至关重要的人群回响，早产儿面临着明显的真皮，偶然的 以及静脉内暴露于邻苯二甲酸盐，无处不在的有机内分泌中分类化学物质，同时住院 新生儿重症监护病房（NICU）。早产婴儿患不良健康的高度患病率 与早期出生儿童的邻苯二甲酸盐暴露有关的影响，尤其是异常 肺功能。环境影响对早产儿童不良后果的贡献是 理解不佳。我们工作的另一个中心宗旨是早产儿可以研究 在普通人群中可能更微妙的暴露结果联系。大型临床研究，例如Echo 在整个早产中出生的参与者允许严格研究这一前提。 通过ECHO计划的下一阶段，我们在用餐中追求以下特定目标： 目标1。利用回声队列协议核心数据元素比较暴露结果 与术语人群相比，早产的关系。 目标2。利用专业数据元素来解决有关早期影响的关键问题 敏感人群的肺部发育中的生命化学暴露，早产儿。 目标3。实施程序以最大程度地保留现有参与者，重点 保持队列多样性和协议保真度。 早产儿的持续参与回声不仅对我们的科学命令至关重要，而且对 同样是整个回声计划，因为早产儿占美国人口的10％以上。