OMENTUM AND TREATMENT OF MORBID OBESITY

大网膜和病态肥胖的治疗

• 批准号: 7605584
• 负责人: Naji N Abumrad
• 金额: $ 6.14万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605584
• 关键词: African American; Computer Retrieval of Information on Scientific Projects Database; Down-Regulation; Funding; Grant; Inflammatory; Institution; Long-Term Effects; Mediating; Metabolic; Morbid Obesity; Omentum; Peptides; Population; Postoperative Period; Refractory; Research; Research Personnel; Resources; Source; United States National Institutes of Health; bariatric surgery; day; insulin sensitivity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central hypotheses of this application is that improvements in insulin sensitivity following bariatric surgery begin early in the postoperative period (10-30 days) and are mediated by changes in the secretion of energy-related peptides, while the long-term effects (greater than 1 month) are mediated by down-regulation of inflammatory factors. Specific Aim 1: Determine the mechanism for the metabolic improvements after RYGB Specific Aim 2: Explore the mechanism for the blunted and delayed metabolic improvement after RYGB in African Americans Specific Aim 3: Explore whether combining omentectomy with RYGB helps accelerate and sustain metabolic improvements especially in the more refractory African American population

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 本申请的中心假设是减肥手术后胰岛素敏感性的改善在术后早期（10-30天）开始开始，并由能量相关肽分泌的变化介导，而长期效应（大于1个月）由炎症因子的下调介导。具体目标1：确定RYGB后代谢改善的机制 具体目标2：探索非裔美国人RYGB后代谢改善迟钝和延迟的机制 具体目标3：探讨网膜切除术与RYGB联合是否有助于加速和维持代谢改善，特别是在更难治的非洲裔美国人人群中