ANGER EXPRESSION, EDNOGENOUS OPHOIDS, AND ACUTE PAIN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的具体目的是确定愤怒唤醒是否是阿片类药物功能障碍和愤怒与疼痛敏感性之间联系的关键因素。健康的正常人将被分配到安慰剂或阿片类药物阻断（50 mg纳洛酮）条件下，并将进行认知任务与骚扰，然后疼痛诱导，或将经历疼痛诱导，然后认知任务。如果愤怒唤醒是引发阿片类药物介导的与愤怒相关的疼痛敏感性差异的关键决定因素，那么我们预计愤怒x药物x任务顺序的相互作用如下：a）在安慰剂下，高愤怒将与更大的疼痛敏感性相关，在遭受骚扰的受试者中最强烈（即愤怒诱导）在疼痛诱导之前; B）内源性阿片样物质的药理学阻断，其是低愤怒中疼痛反应性降低的基础，外的个体将导致愤怒和疼痛敏感性之间的关系对于两个任务顺序变得不显著。总之，在急性愤怒唤起的条件下，药物阿片类药物阻滞预计会使低愤怒个体以类似于高愤怒个体的方式对疼痛刺激做出反应，高愤怒个体预计会显示阿片类药物功能障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Specific Aim of the study is to determine whether anger arousal is a key factor in the emergence of the link between opioid dysfunction and anger-out vis-a-vis pain sensitivity. Healthy normals will be assigned to placebo or opioid blockade (50 mg naltrexone) conditions and will perform either a cognitive task with harassment followed by pain-induction, or will undergo pain induction and then the cognitive task. If anger arousal is a key determinant in eliciting opioid-mediated differences in pain sensitivity associated with anger-out, then we expect anger-out x drug x task order interactions such that: a) under placebo, high anger-out will be related to greater pain sensitivity most strongly among subjects undergoing harassment (i.e. anger induction) prior to pain-induction; b) pharmacological blockade of the endogenous opioids underlying diminished pain responsiveness in low anger-out individuals will result in the relationships between anger-out and pain sensitivity becoming nonsignificant for both task orders. In summary, under conditions of acute anger arousal, pharmacological opioid blockade is expected to make low anger-out individuals react to pain stimulation in a manner similar to high anger-out individuals, who are expected to display opioid dysfunction.