PAIN REGULATORY DYSFUNCTION IN CHRONIC PAIN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标1：研究α 2肾上腺素能机制在介导无痛正常血压人群静息血压和急性疼痛敏感性之间的反向关系中的作用。 具体目标二：确定α-2肾上腺素能功能的变化是否有助于静息血压和急性疼痛敏感性之间关系的慢性疼痛相关改变。 具体目标3：确定压力感受器敏感性的变化是否有助于改变慢性疼痛患者相对于无痛对照组的静息血压和急性疼痛敏感性之间的关系。 具体目标4：确定慢性疼痛相关的疼痛促进通路激活是否有助于改变慢性疼痛患者相对于无痛对照的静息血压和急性疼痛敏感性之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: To examine the role of alpha-2 adrenergic mechanisms in mediating the inverse relationship between resting BP and acute pain sensitivity in pain-free normotensive humans. Specific Aim 2: To determine whether changes in alpha-2 adrenergic function contribute to chronic pain-related alterations in the relationship between resting BP and acute pain sensitivity. Specific Aim 3: To determine whether changes in baroreceptor sensitivity contribute to alterations in the relationship between resting BP and acute pain sensitivity in chronic pain patients relative to pain-free controls. Specific Aim 4: To determine whether chronic pain-related activation of pain facilatory pathways contributes to alterations in the relationship between resting BP and acute pain sensitivity in chronic pain patients relative to pain-free controls.