PACTG P1055: PSYCHIATRIC CO-MORBIDITY IN PERINATALLY HIV CHILDREN AND ADOLESCENT

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 P1055是一项多中心、非治疗、观察性研究，旨在更好地了解HIV对围产期HIV感染儿童和青少年队列中精神疾病发展的影响，并与人口统计学匹配的对照受试者队列进行比较。 这项研究的意义在于它的重点是一个潜在的高风险样本暴露于嗜神经病毒和治疗方案与改变渗透到大脑。 出于本研究的目的，对照组中的受试者将是频率匹配的（即，将按性别和年龄层将6至12岁至12至18岁男性的比例与艾滋病毒感染组的比例相匹配。 受试者在本研究中将不接受治疗;受试者及其父母/主要护理者将回答一系列问卷/测量，这些问卷/测量将用于评估当前精神症状和疾病的患病率和严重程度，并评估随时间的变化。 该研究分为两个部分，即当前精神疾病和症状的患病率和严重程度（第一次研究访视时的精神健康部分）和精神病学随时间的变化（第二次和第三次研究访视时的随访部分）。 此外，围产期HIV感染者和对照受试者（每组100-120例受试者）及其父母/主要照顾者将接受额外措施，以半结构化精神病学访谈的形式，进一步确定HIV感染儿童或青少年和对照受试者精神症状的频率差异，并确定长期随访研究的可行性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. P1055 is a multicenter, non-treatment, observational study designed to better understand the impact of HIV on the development of psychiatric symptomatology in a cohort of perinatally HIV-infected children and adolescents, when compared to a cohort of demographically matched control subjects. The significance of this study rests in its focus on a potentially high-risk sample exposed to a neurotropic virus and therapeutic regimens with altered penetration into the brain. For the purposes of this study, subjects in the control group will be frequency matched (i.e., will be matched with the same percentage of 6 to 12 to 12 to 18 year-old males) to those in the HIV-infected group by gender and age strata. Subjects will not receive treatment in this study; subjects and their parents/primary caregivers will respond to a series of questionnaires/measures which will be used to assess the prevalence and severity of current psychiatric symptoms and disorders and to assess changes over time. The study is divided into two components, the prevalence and severity of current psychiatric disorders and symptoms (Mental Health Component at the first study visit) and changes in symptomatology over time (Follow-Up Component at the second and third study visits). In addition, a subset of perinatally HIV-infected and control subjects (100-120 subjects from each group) and their parents/primary caregivers will receive additional measures, in the form of semi-structured psychiatric interviews, to further identify the differential frequency of psychiatric symptoms in HIV-infected children or adolescents and control subjects and to establish the feasibility of a long-term follow-up study.