University of Colorado Denver Adolescent Trials Network Unit

描述（由申请人提供）：据估计，全世界每年有120万15至24岁的年轻人感染艾滋病毒。在美国，青年人的艾滋病毒感染率最高，2006年所有新感染病例中有34%发生在13-29岁之间。科罗拉多州卫生和环境部的数据表明，感染艾滋病毒的年轻人人数每年都在增加，感染其他性传播疾病的年轻人人数也在稳步增加，这表明大量青少年和年轻人的行为使他们面临感染艾滋病毒的风险。该提案的目标是在丹佛市区建立一个新的青少年试验网络单位。该股将充分参与ATN业务，开展侧重于青少年和年轻人（12-24岁）艾滋病毒感染的初级、二级和三级预防的研究。这项工作将主要在科罗拉多大学丹佛分校附属的儿童医院以及高危青少年接受服务的社区进行。申请人有超过18年参与艾滋病毒感染者和高危人群的多中心临床试验的经验。我们的研究单位在数据质量和对我们参与的临床试验网络的科学议程的贡献方面建立了成就记录。CHIP青年项目是一个强有力的方案，照顾艾滋病毒感染的青年，是牵头机构在丹佛的合作社区联盟，青年艾滋病毒倡导联盟（YHAC），致力于预防艾滋病毒。这些属性定位我们的网站是一个高生产力的ATN单位。该项目的具体目标是：1)将青少年试验网络协议整合到CHIP/CYP的研究和护理操作中；2)扩大和加强现有的社区合作，从而动员社区减少艾滋病毒传播；3)采用创新战略，招募并留住75名以上艾滋病毒感染者和125名艾滋病毒高危青少年和青壮年；4)作为ATN单位保持优异的业绩；5)为ATN的科学议程做出贡献；制定方法确保消费者对科学议程和研究工作的投入。

DESCRIPTION (provided by applicant): An estimated 1.2 million new HIV infections occur among 15 to 24 year olds annually in the world. In the US, the HIV incidence rate in youth is among the highest with 34% of all new infections occurring among 13-29 year olds in 2006. Data from the Colorado Department of Health and Environment indicate an annual increase in the number of young people acquiring HIV infection as well as a steady increase in the number of youth with other sexually transmitted infections, indicating that a large number of adolescents and young adults are participating in behavior that puts them at risk of HIV infection. The goal of this proposal is to establish a new Adolescent Trials Network Unit in metropolitan Denver. The unit will participate fully with the ATN operations to conduct studies focused on primary, secondary and tertiary prevention of HIV infection in adolescents and young adults (age 12-24yr). The work will be take place primarily at The Children's Hospital which is affiliated with University of Colorado Denver as well as in the communities where at-risk youth receive services. The applicant has over 18 years of experience participating in multi-centered clinical trials for HIV infected and at-risk individuals. Our research unit has established a record of achievement in regard to data quality and contributions to the scientific agenda of the clinical trials networks in which we have participated. CHIP Youth Project is a robust program for the care of HIV-infected youth and is the lead agency in Denver's collaborative community consortium, the Youth HIV Advocacy Coalition (YHAC), dedicated to the prevention of HIV. These attributes position our site to be a highly productive ATN unit. The specific aims of the project will be to 1) Integrate Adolescent Trials Network protocols into the research and care operation of CHIP/CYP; 2) Expand and enhance existing community collaborations resulting in community mobilization to reduce HIV transmission; 3) Use innovation strategies to recruit and retain more than 75 HIV infected and 125 HIV at-risk adolescents and young adults; 4) Maintain outstanding performance as an ATN unit; 5) Contribute to the ATN scientific agenda; 6) Develop methods to assure consumer input to scientific agenda and research operations. RELEVANCE: The research conducted in this proposal, in collaboration with other research units and the ATN leadership, will lead to improved interventions to prevent HIV transmission among youth (age 12-24 years) and to better care to prevent disease progression and improve quality of life for youth living with HIV.