IMMUNOGENETICS OF POLYGLANDULAR FAILURE

多腺体衰竭的免疫遗传学

• 批准号: 7605058
• 负责人: GEORGE S EISENBARTH
• 金额: $ 0.26万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605058
• 关键词: Addison' s disease; Adrenal Glands; Adrenal gland hypofunction; Aldosterone; Antibodies; Autoantibodies; Autoimmune Diseases; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Corticotropin; Development; Diagnosis; Diagnostic; Failure; Funding; Grant; Hydrocortisone; Immunogenetics; Institution; Insulin-Dependent Diabetes Mellitus; Life; Patients; Production; Protocols documentation; Research; Research Personnel; Resources; Risk; Source; Steroid 21-Monooxygenase; Symptoms; Testing; United States National Institutes of Health; experience; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Through this protocol we are attempting to understand the association of autoimmune diseases and type 1 diabetes. In particular, subjects with type 1 diabetes are at an increased risk for Addison's disease. Addison's disease is adrenal gland failure and is characterized by cortisol and aldosterone insufficiency. Its onset is often insidious with subjects experiencing many years of symptoms prior to being diagnosed. However, it is life threatening and un- or misdiagnosed Addison's disease can be associated with adrenal crisis and death. Addison's disease is associated with the production of 21-hydroxylase autoantibodies. These autoantibodies are present in 1.5% of our patients with type 1 diabetes and the production of these autoantibodies alerts us to the risk for significant illness with adrenal insufficiency. These antibodies may be present for many years prior to the development of adrenal gland failure. Assessment of adrenal gland function requires stimulation testing, in particular ACTH stimulation. ACTH stimulates the adrenal gland to produce cortisol and an inadequate response of cortisol is diagnostic of adrenal insufficiency. Through this protocol subjects with 21-hydroxylase antibodies are evaluated for adrenal insufficient with ACTH stimulation testing.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 通过这个方案，我们试图了解自身免疫性疾病和1型糖尿病的关联。 特别地，患有1型糖尿病的受试者患阿狄森氏病的风险增加。 阿狄森氏病是肾上腺衰竭，其特征是皮质醇和醛固酮不足。 它的发作通常是潜伏的，受试者在被诊断之前经历多年的症状。 然而，它是危及生命的，未诊断或误诊的阿狄森氏病可与肾上腺危象和死亡有关。 阿狄森氏病与21-羟化酶自身抗体的产生有关。 这些自身抗体存在于1.5%的1型糖尿病患者中，这些自身抗体的产生提醒我们肾上腺功能不全的重大疾病的风险。 这些抗体可能在肾上腺衰竭发生前存在多年。 肾上腺功能的评估需要刺激试验，特别是ACTH刺激。 促肾上腺皮质激素刺激肾上腺产生皮质醇，皮质醇反应不足可诊断为肾上腺功能不全。 通过该方案，用ACTH刺激试验评价具有21-羟化酶抗体的受试者的肾上腺不足。