OUTCOME MEASURES FOR POST-THROMBOTIC SYNDROME

血栓后综合征的结果测量

• 批准号: 7605075
• 负责人: NEIL A GOLDENBERG
• 金额: $ 0.11万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605075
• 关键词: Age; Anatomy; Child; Computer Retrieval of Information on Scientific Projects Database; Confidence Intervals; Control Groups; Funding; Gender; Grant; Institution; Intention; Limb structure; Measures; Outcome Measure; Pain; Pharmacotherapy; Physical assessment; Population; Postphlebitic Syndrome; Recruitment Activity; Research; Research Personnel; Resources; Source; Swelling; Thigh structure; Thrombosis; United States National Institutes of Health; Upper arm; Venous Thrombosis; comparative; indexing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this study is to recruit a control group of healthy children - for an existing study of children with venous thrombosis. This study will assess the validity of three measures of Post Thrombotic Syndrome (PTS) in children with venous thrombosis: 1) Limb circumference difference - as an index of swelling, measured at the same anatomic level separately for upper and lower arms, thighs, and calves; 2) a PTS physical assessment scale (CEAP); and 3) a Pain Scale (Wong-Baker FACES). Discriminant validity will be assessed by comparing results on these measures for children with venous thrombosis versus age+gender matched healthy children who have never suffered a thrombosis. We hope to validate these measures, so that they might later be used as PTS outcome measures in a comparative drug therapy trial. The intention of this study is not to establish narrow confidence-interval population norms on these measures.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是招募一个健康儿童的对照组-用于现有的静脉血栓形成儿童研究。 本研究将评估静脉血栓形成儿童中血栓后综合征（PTS）的三种测量方法的有效性：1）肢体周长差-作为肿胀指数，分别在上臂和下臂、大腿和小腿的相同解剖水平测量; 2）PTS身体评估量表（CEAP）; 3）疼痛量表（Wong-Baker FACES）。 将通过比较静脉血栓形成儿童与从未发生血栓形成的年龄+性别匹配的健康儿童的这些测量结果来评估判别有效性。 我们希望验证这些措施，使他们以后可能会被用作PTS的结果措施，在比较药物治疗试验。 本研究的目的不是建立狭窄的置信区间的人口规范，这些措施。