WOMEN'S HEALTHY EATING AND LIVING TRIAL IN THE BAY AREA

湾区女性健康饮食和生活试验

• 批准号: 7605157
• 负责人: Marcia L Stefanick
• 金额: $ 3.74万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605157
• 关键词: American; Antioxidants; Area; California; Calories; Cancer Center; Cancer Survivor; Cereals; Characteristics; Class; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Counseling; Diagnosis; Diet; Dietitian; Disease; Disease regression; Eating; Edible Plants; End Point; Enrollment; Estrogens; Event; Fatty acid glycerol esters; Fiber; Fruit; Funding; Goals; Grant; Guidelines; Institution; Instruction; Intervention; Juice; Life; Living Wills; Localized; Malignant Neoplasms; Medical; National Cancer Institute; Nutrient; Participant; Phytochemical; Plasma; Randomized Controlled Clinical Trials; Recurrence; Research; Research Personnel; Resources; Risk; Second Primary Cancers; Source; Staging; Telephone; Testing; United States National Institutes of Health; Vegetables; Woman; cooking; day; follow-up; fruits and vegetables; insight; malignant breast neoplasm; oncology; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Evidence suggests that regression and progression of localized breast cancer, after the disease has been diagnosed and treated by conventional means, might be reduced by 30-50% if current dietary guidelines for Americans were enriched markedly for edible plants and fiber and had a reduced fat content. The Women's Healthy Eating and Living (WHEL) study, a 6-yr multicenter randomized trial of 3,104 cancer survivors, is comparing the effect of receiving instruction on the dietary guidelines of the National Cancer Institute (NCI), i.e. <30% of calories from fat, = 5 servings/day of fruits and vegetables, = 6 servings/day of grains with a dietary counseling program which has the following dietary goals: 15-20% of calories from total fat, = 30 gm of fiber/day, = 5 servings of vegetables plus 16 oz/day of vegetable juice, with an emphasis on "nutrient-dense" vegetables, i.e. those with a high content of antioxidants and specific phytochemicals, and = 3 servings/day of fruit. WHEL Study participants were within 4 yrs of their diagnosis of stage I (>1 cm), II, and IIIA disease and had completed conventional therapy. The Northern California Cancer Center, one of six clinical centers, enrolled 517 women, 355 of whom are being tested and followed at the Stanford GCRC. In addition to telephone counseling by USCD Coordinating Center staff, participants attend regular cooking classes at the GCRC, which are directed by registered dietitians who also provide interim counseling. Medical follow-up is by usual oncology practice to determine clinical study endpoints of disease-free and total survival. WHEL will determine if the risk of recurrence can be reduced in the diet-intervention group by 20%, versus the NCI-diet control group, at 6 yrs. To gain insight into mechanisms of how diet might influence the disease, WHEL is comparing plasma carotinoids and endogenous estrogen levels in women who have a secondary cancer event with levels in women whose cancers have not yet recurred, but who are matched for other characteristics from both the study and control groups.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 有证据表明，在通过常规方法诊断和治疗局部乳腺癌后，如果美国人现行的饮食指南显着富含可食用植物和纤维并减少脂肪含量，则局部乳腺癌的消退和进展可能会减少 30-50%。 女性健康饮食和生活 (WHEL) 研究是一项针对 3,104 名癌症幸存者的为期 6 年的多中心随机试验，正在比较接受国家癌症研究所 (NCI) 饮食指南指导（即 <30% 的热量来自脂肪、= 5 份/天的水果和蔬菜、= 6 份/天的谷物）与饮食咨询计划的效果，该计划具有以下饮食目标：15-20% 总脂肪中的卡路里，= 30 克纤维/天，= 5 份蔬菜加 16 盎司/天蔬菜汁，重点是“营养密集”蔬菜，即抗氧化剂和特定植物化学物质含量高的蔬菜，以及= 3 份/天水果。 WHEL 研究参与者在诊断出 I 期（>1 cm）、II 期和 IIIA 期疾病后 4 年内完成了常规治疗。 北加州癌症中心是六个临床中心之一，招募了 517 名女性，其中 355 名正在斯坦福 GCRC 接受检测和随访。 除了 USCD 协调中心工作人员的电话咨询外，参与者还参加 GCRC 的定期烹饪课程，这些课程由注册营养师指导，同时提供临时咨询。 医学随访是通过通常的肿瘤学实践来确定无病生存和总生存的临床研究终点。 WHEL 将确定饮食干预组与 NCI 饮食对照组相比，6 岁时复发风险是否可以降低 20%。 为了深入了解饮食如何影响疾病的机制，WHEL 将患有继发性癌症事件的女性的血浆类胡萝卜素和内源性雌激素水平与癌症尚未复发但与研究组和对照组的其他特征相匹配的女性的血浆类胡萝卜素和内源性雌激素水平进行比较。