Microtubule severing: a role in mammalian oocyte and embryo viability?
Microtubule severing: a role in mammalian oocyte and embryo viability?
微管切断：对哺乳动物卵母细胞和胚胎活力的作用？
批准号：
nhmrc : 1146468
负责人：
Dr Greg Fitzharris
金额：
$41.36万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2018
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2018-01-01 至 2020-12-31
中文摘要
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英文摘要
In all cells, cell division is controlled by a microtubule based structure known as the spindle. Abnormal function of this spindle leads to loss and gain of chromosomes that in oocytes causes early embryo loss and in cells of the body it causes cancer and cell death. We will investigate a family of proteins that modify microtubules and explore the role they play in ensuring cell division happnens safely.
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