Microtubule severing: a role in mammalian oocyte and embryo viability?

微管切断：对哺乳动物卵母细胞和胚胎活力的作用？

• 批准号: nhmrc : GNT1146468
• 负责人: Dr Greg FitzHarris
• 金额: $ 61.17万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microtubule-severing-role-embryo-viability/1348761
• 关键词: Microtubule; severing; role; mammalian; oocyte

In all cells, cell division is controlled by a microtubule based structure known as the spindle. Abnormal function of this spindle leads to loss and gain of chromosomes that in oocytes causes early embryo loss and in cells of the body it causes cancer and cell death. We will investigate a family of proteins that modify microtubules and explore the role they play in ensuring cell division happnens safely.

在所有的细胞中，细胞分裂都是由一种叫做纺锤体的微管结构控制的。这种纺锤体的异常功能导致染色体的丢失和获得，在卵母细胞中导致早期胚胎丢失，在身体细胞中导致癌症和细胞死亡。我们将研究修饰微管的蛋白质家族，并探索它们在确保细胞分裂安全发生中所起的作用。