Setting effectiveness and translational research priorities to improve COPD care

描述（由申请人提供）：与美国其他主要死因不同，慢性阻塞性肺病（COPD）的患病率和健康负担持续上升。研究表明，COPD患者的护理和结局在不同的临床环境中差异很大，许多患者没有从临床试验中确定的治疗进展中获益（“研究与实践差距”）。此外，COPD通常存在于复杂患者（患有2种或2种以上慢性健康状况的患者）中，并且由于COPD的恶化很常见，因此COPD患者经常在急性和慢性医疗保健环境之间循环。共病健康状况对治疗决策和COPD健康结局的影响，以及与不同医疗环境之间的护理过渡相关的困难，导致了COPD研究与实践的差距。基于COPD结局的临床有效性和研究转化网络（CONCERT）建议召开研究开发会议（CONCERT共识会议和研讨会，CCW），以：a）制定有效性和转化性COPD研究的研究议程并确定优先顺序，以及B）加速设计良好的多中心转化研究的发展，以改善COPD社区的护理和结局。在第1年，共识会议（2009年5月21-22日;加利福尼亚州圣地亚哥）和研讨会（2009年8月7日; 2009年9月4日; 2009年10月2日;伊利诺伊州芝加哥）将讨论慢性病护理/护理协调。在第2年，共识会议（2010年5月20日至21日;新奥尔良，洛杉矶）和研讨会（2010年8月6日; 2010年9月3日; 2010年10月1日;芝加哥，IL）将讨论COPD护理中的急性护理/过渡。CCW将由广泛的利益相关者参加，包括患者倡导团体，健康计划，保险公司，专业协会和政府机构。结果 CCWs框架将被广泛传播，并将为开发利益相关者支持的多中心网络提供基础，以开展有效性和转化研究，以改善美国的COPD护理。CCWs框架将很容易转移到其他慢性健康状况，这些状况也面临着缩小研究与实践差距的类似障碍。

DESCRIPTION (provided by applicant): Unlike other leading causes of death in the U.S., the prevalence and health burden of chronic obstructive pulmonary disease (COPD) continues to rise. Studies indicate that the care and outcomes of patients with COPD vary substantially across different clinical settings and that many patients are not benefiting from advances in treatment identified in clinical trials ('research-to-practice gap'). In addition, COPD often exists in complex patients (patients with 2 or more chronic health conditions) and, because exacerbations of COPD are common, patients with COPD often cycle between acute and chronic healthcare settings. Effects of co-morbid health conditions on treatment decisions and COPD health outcomes, as well as the difficulties associated with transitions in care between different healthcare settings, contribute to the research-to-practice gap in COPD. The COPD Outcomes-based Network for Clinical Effectiveness and Research Translation (CONCERT) proposes to convene research development conferences (CONCERT Consensus Conferences and Workshops, CCWs) to: a) Develop and prioritize a research agenda for effectiveness and translational COPD research, and b) Accelerate the development of well-designed multi-center translational studies to improve the care and outcomes of COPD communities. In Year 1, the consensus conference (May 21-22, 2009; San Diego, CA) and workshops (August 7, 2009; September 4, 2009; October 2, 2009; Chicago, IL) will address Chronic Care/Care Coordination in COPD. In Year 2, the consensus conference (May 20-21, 2010; New Orleans, LA) and workshops (August 6, 2010; September 3, 2010; October 1, 2010; Chicago, IL) will address Acute Care/Transitions in COPD care. The CCWs will be attended by a broad cross-section of stakeholders, including patient advocacy groups, health plans, insurers, professional societies, and government agencies. Results will be widely disseminated and will provide the basis to develop a stakeholder supported multi-center network to carry out effectiveness and translational research studies to improve COPD care in the U.S. The CCWs framework will be easily transferable to other chronic health conditions, which also face similar barriers to narrowing the research-to-practice gap.