Setting effectiveness and translational research priorities to improve COPD care

设定有效性和转化研究重点以改善慢性阻塞性肺病护理

• 批准号: 7679021
• 负责人: Jerry A. Krishnan
• 金额: $ 10万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7679021
• 关键词: Setting; effectiveness; translational; research; priorities

DESCRIPTION (provided by applicant): Unlike other leading causes of death in the U.S., the prevalence and health burden of chronic obstructive pulmonary disease (COPD) continues to rise. Studies indicate that the care and outcomes of patients with COPD vary substantially across different clinical settings and that many patients are not benefiting from advances in treatment identified in clinical trials ('research-to-practice gap'). In addition, COPD often exists in complex patients (patients with 2 or more chronic health conditions) and, because exacerbations of COPD are common, patients with COPD often cycle between acute and chronic healthcare settings. Effects of co-morbid health conditions on treatment decisions and COPD health outcomes, as well as the difficulties associated with transitions in care between different healthcare settings, contribute to the research-to-practice gap in COPD. The COPD Outcomes-based Network for Clinical Effectiveness and Research Translation (CONCERT) proposes to convene research development conferences (CONCERT Consensus Conferences and Workshops, CCWs) to: a) Develop and prioritize a research agenda for effectiveness and translational COPD research, and b) Accelerate the development of well-designed multi-center translational studies to improve the care and outcomes of COPD communities. In Year 1, the consensus conference (May 21-22, 2009; San Diego, CA) and workshops (August 7, 2009; September 4, 2009; October 2, 2009; Chicago, IL) will address Chronic Care/Care Coordination in COPD. In Year 2, the consensus conference (May 20-21, 2010; New Orleans, LA) and workshops (August 6, 2010; September 3, 2010; October 1, 2010; Chicago, IL) will address Acute Care/Transitions in COPD care. The CCWs will be attended by a broad cross-section of stakeholders, including patient advocacy groups, health plans, insurers, professional societies, and government agencies. Results will be widely disseminated and will provide the basis to develop a stakeholder supported multi-center network to carry out effectiveness and translational research studies to improve COPD care in the U.S. The CCWs framework will be easily transferable to other chronic health conditions, which also face similar barriers to narrowing the research-to-practice gap.

描述(申请人提供)：与美国其他主要死亡原因不同，慢性阻塞性肺疾病(COPD)的患病率和健康负担持续上升。研究表明，慢性阻塞性肺疾病患者的护理和结果在不同的临床环境中有很大差异，许多患者没有从临床试验中确定的治疗进展中受益(研究与实践之间的差距)。此外，COPD通常存在于复杂的患者(有两种或两种以上慢性健康状况的患者)中，而且由于COPD的恶化很常见，COPD患者经常在急性和慢性医疗保健环境之间循环。并存的健康状况对治疗决策和COPD健康结果的影响，以及与不同医疗保健环境之间的护理过渡相关的困难，导致了COPD研究与实践之间的差距。以COPD成果为基础的临床有效性和研究转化网络(CONSTUTE)建议召开研究发展会议(COPD共识会议和研讨会，CCW)，以：a)制定COPD有效性和转化性研究的研究议程并确定优先顺序，以及b)加快开发设计良好的多中心转化性研究，以改善COPD社区的护理和结果。在第一年，共识会议(2009年5月21日至22日，加利福尼亚州圣地亚哥)和研讨会(2009年8月7日；2009年9月4日；2009年10月2日；伊利诺伊州芝加哥)将讨论慢性阻塞性肺病的慢性护理/护理协调。在第二年，共识会议(2010年5月20-21日，洛杉矶新奥尔良)和研讨会(2010年8月6日；2010年9月3日；2010年10月1日；伊利诺伊州芝加哥)将讨论COPD护理中的急性护理/过渡。CCW将有广泛的利益相关者参加，包括患者倡导团体、健康计划、保险公司、专业协会和政府机构。结果 CCW框架将被广泛传播，并将为发展利益相关者支持的多中心网络提供基础，以开展有效性和转化性研究，以改善美国的COPD护理。CCW框架将很容易转移到其他慢性健康疾病，这些疾病在缩小研究与实践之间的差距方面也面临类似的障碍。

项目成果

Comparative effectiveness research in chronic obstructive pulmonary disease.

慢性阻塞性肺疾病的比较有效性研究。

• DOI: 10.2217/cer.11.10
• 发表时间: 2012
• 期刊: Journal of comparative effectiveness research
• 影响因子: 2.1
• 作者: Mularski,RichardA;McBurnie,MaryAnn;Lindenauer,PeterK;Lee,ToddA;Vollmer,WilliamM;Au,DavidH;Carson,ShannonS;Krishnan,JerryA;CONCERTInvestigatorConsortium
• 通讯作者: CONCERTInvestigatorConsortium