Translating the DPP in an HMO Setting: Telephone Intervention Planning Grant

描述(申请人提供)：摘要/摘要：本提案响应PAR-06-358“预防和控制糖尿病和肥胖的翻译研究规划资助”。据估计，到2050年，美国将有3000万成年人患有2型糖尿病。导致这一全国性趋势的原因是肥胖症的流行。三项随机试验已经证明，强化的行为干预可以预防或推迟糖尿病的发病。这项先导性研究的目的是为未来的随机对照第三阶段试验提供信息，该试验以人群为基础，通过电话、锻炼和减肥干预，将糖尿病预防计划的结果转化为实践。1：1电话干预将与常规护理(每组30名参与者，男性和女性各15名)进行比较。干预将以每周20分钟的电话进行，为期10周，其中维护电话每周3次，每月2次，24周内总共15次。研究结果将在基线、10周和24周进行测量。我们的具体目标是：1)评估基于电话的减肥和运动干预的可行性和可接受性，包括招募、干预接受和继续参与；2)对干预的有效性进行初步评估，包括干预组和普通护理组在10周和24周的减肥以及干预组和普通护理组的体力活动；以及3)为全面有效性试验的设计和实施提供信息，包括完善干预、改进测量策略、获取数据以完善样本量估计，并使用干预时间记录来估计项目成本。 叙述：糖尿病预防项目和其他干预试验表明，强化减肥和运动干预可以降低糖尿病风险。公共卫生面临的挑战是将这些功效试验的结果转化为有效的、以人群为基础的计划，这些计划可以经济高效地惠及大量高危人群，实现类似的减肥和锻炼目标，并随着时间的推移维持这些变化。我们的目标是将民进党转化为应对这一挑战的电话干预。

DESCRIPTION (provided by applicant): SUMMARY/ABSTRACT: This proposal responds to PAR-06-358 "Planning Grants for Translational Research for the Prevention and Control of Diabetes and Obesity." It is estimated that 30 million U.S. adults will have type 2 diabetes by 2050. Contributing to this national trend is the obesity epidemic. Three randomized trials have demonstrated that intensive behavioral interventions can prevent or delay the onset of diabetes. The purpose of this pilot study is to inform a future randomized, controlled, Phase III trial of a population-based, telephonic, exercise and weight loss intervention to translating the findings of the Diabetes Prevention Program into practice. The 1:1 telephonic intervention will be compared to usual care (30 participants in each group, 15 male and 15 female). The intervention will be delivered in weekly, 20 minute calls, for 10 weeks, with maintenance calls biweekly times 3, and monthly times 2, for a total of 15 calls over 24 weeks. Study outcomes will be measured at baseline, 10 weeks, and 24 weeks. Our specific aims are to: 1) Evaluate the feasibility and acceptability of a telephone-based weight loss and exercise intervention, including recruitment, intervention acceptance, and continued participation; 2) Conduct a preliminary evaluation of the intervention's effectiveness including, weight loss at 10 and 24 weeks in the intervention vs. usual-care groups and physical activity in the intervention vs. usual-care groups; and 3) Inform the design and implementation of a full-scale effectiveness trial, including refining the intervention, refining measurement strategies, obtaining data to refine sample size estimates, and using intervention time-logs to estimate program costs. NARRATIVE: The Diabetes Prevention Project and other intervention trials showed that intensive weight loss and exercise interventions can reduce diabetes risk. The public health challenge is to translate the results of these efficacy trials into effective, population-based programs that can cost- effectively reach large numbers of people at risk, achieve similar weight loss and exercise goals, and sustain these changes over time. Our goal is to translate the DPP into a telephone-based intervention that meets this challenge.