EVALUATE THE INTRADUODENAL DELIVER OF TOTAL PROTEASE AND LIPASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究和我们实验室对反馈抑制胰腺分泌的持续研究的最终期望是开发一种有效的胰酶制剂，能够持续地将其化合物释放到十二指肠。胰腺脂肪酶和蛋白水解酶的输送将使用肠道抽吸方法进行评估，本实验室已在许多场合成功地使用了该方法。将对12名患有慢性胰腺炎的患者进行研究，其中6名患者的粪便脂肪排泄增加(胰腺功能不全)，6名患者有腹痛，但尚未发展为胰腺功能不全。将比较两种胰酶制剂中脂肪酶和蛋白水解酶的释放情况，分别是涂布Eudragit LD30的超酶MT 20和涂布HP 55的超酶MT 20。这项研究将证明这两种制剂的疗效。无论是治疗脂肪吸收不良还是腹痛，这项技术对于所有胰腺酶制剂的评估都是必要的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ultimate expectation of this study and of the continued studies of feedback inhibition of pancreatic secretion in our laboratory is to develop a potent pancreatic enzyme preparation which can release its compounds consistently into the duodenum. Delivery of pancreatic lipase and proteases will be evaluated utilizing an intestinal aspiration methodology that this laboratory has utilized successfully on numerous occasions. Twelve subjects with chronic pancreatitis will be studied, six of whom will have excretion of elevated amounts of fecal fat (pancreatic insufficiency) and six with abdominal pain but who have not yet developed insufficiency. The delivery of lipase and protease will be compared in two pancreatic enzyme preparations, Ultrase MT 20 with Eudragit LD 30 coating and Ultrase MT 20 with HP 55 coating. This study will demonstrate the efficacy of the two preparations. This technique is a necessity for the evaluation of all pancreatic enzyme preparations whether it is for the treatment of fat malabsorption or abdominal pain.