A SINGLE-DOSE, OPEN-LABEL, RANDOMIZED, CROSSOVER STUDY TO EVALUATE INTRADUODENAL

评估十二指肠内的单剂量、开放标签、随机、交叉研究

• 批准号: 7950770
• 负责人: Phillip TOSKES
• 金额: $ 3.28万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950770
• 关键词: Abdominal Pain; Amylases; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Cross-Over Studies; Dose; Duodenum; Evaluation; Excretory function; Exocrine pancreatic insufficiency; Fasting; Fatty acid glycerol esters; Feedback; Funding; Grant; Institution; Intestines; Laboratories; Lipase; Malabsorption Syndromes; Methodology; Pancreas; Pancrease; Pancreatic enzyme; Peptide Hydrolases; Preparation; Randomized; Research; Research Personnel; Resources; Source; Techniques; United States National Institutes of Health; chronic pancreatitis; expectation; feeding; open label; pancreatic juice

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ultimate expectation of this study and of the continued studies of feedback inhibition of pancreatic secretion in our laboratory is to develop a potent pancreatic enzyme preparation which can release its compounds consistently into the duodenum. Delivery of pancreatic lipase, amylase and protease will be evaluated utilizing an intestinal aspiration methodology that this laboratory has utilized successfully on numerous occasions. Twelve subjects with chronic pancreatitis will be studied, all of whom will have excretion of elevated amounts of fecal fat- pancreatic insufficiency. The delivery of lipase, amylase and protease will be compared in a fasted and fed state with and without the addition of pancreatic enzymes. This study will demonstrate the efficacy of PANCREASE MT. This technique is a necessity for the evaluation of all pancreatic enzyme preparations whether it is for the treatment of fat malabsorption or abdominal pain.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究和我们实验室对反馈抑制胰腺分泌的持续研究的最终期望是开发一种有效的胰酶制剂，能够持续地将其化合物释放到十二指肠。胰腺脂肪酶、淀粉酶和蛋白酶的输送将使用肠道吸入法进行评估，本实验室已在许多场合成功地使用了这种方法。将对12名慢性胰腺炎患者进行研究，所有患者都将出现排泄量增加的粪便脂肪-胰腺功能不全。脂肪酶、淀粉酶和蛋白酶的输送将在禁食和喂食状态下进行比较，其中添加和不添加胰酶。这项研究将证明胰腺MT的疗效。无论是治疗脂肪吸收不良还是腹痛，这项技术对于所有胰腺酶制剂的评估都是必要的。