A SINGLE-DOSE, OPEN-LABEL, RANDOMIZED, CROSSOVER STUDY TO EVALUATE INTRADUODENAL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究和我们实验室对胰腺分泌反馈抑制的持续研究的最终期望是开发一种有效的胰酶制剂，该制剂可以持续释放其化合物进入十二指肠。 胰脂肪酶、淀粉酶和蛋白酶的递送将使用本实验室已多次成功使用的肠道抽吸方法进行评价。 将研究12例慢性胰腺炎受试者，所有受试者均将排泄大量粪便脂肪-胰腺功能不全。 将在禁食和进食状态下比较添加和不添加胰酶的脂肪酶、淀粉酶和蛋白酶的递送。 本研究将证明PANCREASE MT的疗效。 该技术是评价所有胰酶制剂的必要条件，无论是用于治疗脂肪吸收不良还是腹痛。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ultimate expectation of this study and of the continued studies of feedback inhibition of pancreatic secretion in our laboratory is to develop a potent pancreatic enzyme preparation which can release its compounds consistently into the duodenum. Delivery of pancreatic lipase, amylase and protease will be evaluated utilizing an intestinal aspiration methodology that this laboratory has utilized successfully on numerous occasions. Twelve subjects with chronic pancreatitis will be studied, all of whom will have excretion of elevated amounts of fecal fat- pancreatic insufficiency. The delivery of lipase, amylase and protease will be compared in a fasted and fed state with and without the addition of pancreatic enzymes. This study will demonstrate the efficacy of PANCREASE MT. This technique is a necessity for the evaluation of all pancreatic enzyme preparations whether it is for the treatment of fat malabsorption or abdominal pain.