ALTERED CALCIUM HOMEOSTASIS IN NEONATES ASSOCIATED WITH GENTAMICIN DOSING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 2000年4月，在我们的机构中，足月和近足月新生儿的庆大霉素给药从q12 h间隔改为q24 h间隔。 在随后的15个月内，我们发现低钙血症的发生率（3.5%）高于在剂量变化前15个月内庆大霉素q12 h给药时新生儿保育室观察保育室所有婴儿病例的回顾性审查中检测到的发生率（0.4%）。先前的研究已经证明庆大霉素给药后尿钙排泄增加，但没有记录血清钙水平的变化。 我们认为庆大霉素不仅改变尿钙，而且改变血清钙。 我们计划测量三组婴儿的血清和尿液电解质：25名婴儿接受q12 h庆大霉素，25名婴儿接受q24 h庆大霉素，10名对照婴儿未接受庆大霉素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In our institution, gentamicin dosing for term and near-term neonates changed in April 2000 from a q12h interval to a q24h interval. During the ensuing 15 months, we discovered a higher incidence (3.5%) of hypocalcemia compared to the incidence (0.4%) detected in a retrospective review of cases of all infants admitted to the Observation Nursery within the Newborn Nursery during the 15 months prior to the dosage change when gentamicin as given q12h. Previous studies have demonstrated increased urinary excretion of calcium with gentamicin administration, but have not documented alterations in serum calcium levels. We propose that administration of gentamicin alters not only urinary calcium but also serum calcium. We plan to measure serum and urine electrolytes in three groups of infants: 25 infants receiving q12h gentamicin, 25 infants receiving q24h gentamicin, and 10 control infants not receiving gentamicin.