SKIN SURFACE COOLING TO IMPROVE ORTHOSTATIC TOLERANCE AFTER PROLONGED BED REST

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 直立性不耐受是太空飞行后、长时间卧床休息后以及超过50万患有特发性直立性不耐受的美国人中常见的事件。在太空飞行中，25-66%的宇航员在着陆后2-3小时的站立测试中出现晕厥或晕厥症状。 此外，当重力大于1.0 Gz（即，头到脚矢量）持续10-15分钟，并且峰值高达1.8 Gz时，许多宇航员在航天飞机再入期间经历直立性低血压/不耐受。由于宇航员明显的操作和安全问题，这种高发生率的立位不耐受引起了NASA的极大关注。 因此，美国航天局高度优先重视确定有效的对策，以减少与长期微重力暴露有关的立位不耐受的发生率。 识别这样的对策也可能有利于个人与特发性立位不耐受。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Orthostatic intolerance is a common occurence following space flight, following prolonged bed rest, and in over 500,000 Americans who suffer from idiopathic orthostatic intolerance. With respect to space flight, 25-66% of all astronauts experience syncope or syncopal symptoms during a stand test 2-3 hours after landing. In addition, many astronauts experience orthostatic hypotension/intolerance during reentry of the space shuttle when gravitational forces are greater than 1.0 Gz (i.e. head to foot vector) for 10-15 min, and peak as high as 1.8 Gz. This high incidence of orthostatic intolerance is of substantial concern to NASA due to obvious operational and safety issues for the astronauts. Thus, NASA has placed a high priority on identifying an effective countermeasure to reduce the incidence of orthostatic intolerance associated with prolonged microgravity exposure. Identification of such a countermeasure may also benefit individuals with idiopathic orthostatic intolerance.