THE GENETICS OF CHOLESTEROL ABSORPTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 血浆低密度脂蛋白-胆固醇是一种关键的心血管危险因素，它与饮食中胆固醇的吸收程度直接相关。个体之间的遗传差异对胆固醇吸收的差异有很大影响。最近，编码一种膜蛋白的基因NPC1L1被认为参与了食物中胆固醇从肠腔到肠细胞的转运。该项目的目标是确定NPC1L1的序列变异是否会导致胆固醇吸收分数的差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Plasma levels of LDL-cholesterol, a key cardiovascular risk factor, are directly related to the fractional absorption of dietary cholesterol. Genetic differences between individuals contribute significantly to differences in cholesterol absorption. Recently a gene NPC1L1, encoding a membrane protein has been implicated in mediating transport of dietary cholesterol from the gut lumen into enterocytes. The goal of this project is to determine if sequence variations in NPC1L1 contribute to differences in fractional absorption of cholesterol.