THE GENETICS OF CHOLESTEROL ABSORPTION

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 LDL-胆固醇的血浆水平，一个关键的心血管危险因素，直接关系到膳食胆固醇的吸收分数。 个体之间的遗传差异对胆固醇吸收的差异有很大影响。 最近，编码膜蛋白的基因NPC 1 L1已经涉及介导膳食胆固醇从肠腔转运到肠上皮细胞。 本项目的目标是确定NPC 1 L1的序列变异是否有助于胆固醇吸收分数的差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Plasma levels of LDL-cholesterol, a key cardiovascular risk factor, are directly related to the fractional absorption of dietary cholesterol. Genetic differences between individuals contribute significantly to differences in cholesterol absorption. Recently a gene NPC1L1, encoding a membrane protein has been implicated in mediating transport of dietary cholesterol from the gut lumen into enterocytes. The goal of this project is to determine if sequence variations in NPC1L1 contribute to differences in fractional absorption of cholesterol.