How does dietary cholesterol induce non-alcoholic steatohepatitis?

膳食胆固醇如何诱发非酒精性脂肪性肝炎？

• 批准号: nhmrc : 1108422
• 负责人: Prof Christopher Liddle
• 金额: $ 55.23万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-dietary-cholesterol-alcoholic-steatohepatitis/663043
• 关键词: How; does; dietary; cholesterol; induce

Non-alcoholic fatty liver disease is the most common liver disease that can progress to non-alcoholic steatohepatitis (NASH), cirrhosis and liver cancer. Dietary cholesterol is a major risk factor for NASH. We can demonstrate that cholesterol changes the gut bacteria. These bacteria generate toxic chemicals (bile acids) that signal to the liver and induce NASH. In this project, we use novel ways to clarify the mechanisms of liver inflammation and test novel therapeutic approaches to reverse it.

非酒精性脂肪肝是最常见的肝脏疾病，可进展为非酒精性脂肪性肝炎 (NASH)、肝硬化和肝癌。膳食胆固醇是 NASH 的主要危险因素。我们可以证明胆固醇会改变肠道细菌。这些细菌产生有毒化学物质（胆汁酸），向肝脏发出信号并诱发 NASH。在这个项目中，我们使用新方法来阐明肝脏炎症的机制，并测试新的治疗方法来逆转它。