LOW FAT DIET AND BREAST CANCER RECURRENCE - OUTCOME TRIAL WINS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 2004年5月，随着对联合国临床中心的资助结束，积极互动阶段也同时结束。 根据2003年10月31日之前的最后一次预定数据分析，评估膳食脂肪对乳腺癌复发影响的初步结果在2005年6月的美国临床肿瘤学会（ASCO）年会全体会议上公布。 在ASCO提交报告时，人们认识到这些结论是初步的，需要采取进一步的后续行动。 从国家癌症研究所获得了额外的资金支持，以允许进行一次研究扩展，以完成原始研究设计的随访持续时间。 研究扩展的主要目的是提供关于低脂肪饮食计划对乳腺癌复发的潜在影响的额外证据。 初步研究结果表明，以减少脂肪为目标的饮食调整计划可能会减少乳腺癌的复发。 该研究的主要目的是提供关于这一问题的更明确的证据。 我们希望了解在与研究营养学家接触结束后，最初看到的趋势是否会继续下去，以及女性选择什么样的饮食。 此外，如果变化是不同的妇女谁是在干预组（要求改变他们的饮食以前）或对照组。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The WINS active interaction phase ended concurrently with the end of funding to the WINS Clinical Centers in May, 2004. Based on the last scheduled data analysis incorporating clinical outcomes available through October 31, 2003, preliminary results from WINS evaluating dietary fat influence on breast cancer recurrence were presented at a plenary session of the American Society of Clinical Oncology (ASCO) annual meeting in June of 2005. It was recognized at the time of the ASCO WINS report that the conclusions were preliminary and further follow-up was required. Additional funding support has been obtained from the National Cancer Institute to allow for a WINS Extension to complete the original study design follow-up duration. The primary objective of the WINS Extension is to provide additional evidence regarding the potential influence of the WINS low fat eating plan on breast cancer recurrence. The preliminary WINS results suggested that the dietary modification program targeting fat reduction may reduce breast cancer recurrences. The main purpose of the WINS extension study is to provide more definitive evidence regarding this issue. We hope to learn if the trends initially seen continue after contact with study nutritionists has ended and what diet women choose. Also, if changes are different for women who were in the intervention group (asked to change their diet previously) or the comparison group.