LONG TERM EFFECTS OF SUBCLINICAL CAD ON CARDIAC FUNCTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 南湾心脏观察(SBHW)的研究证实，在无症状的高危成年人中，心脏中的钙(冠状钙)与心脏病之间存在明确但不完美的关系。我们已经确定，这种关系在糖尿病受试者中减少，并且在冠脉钙的存在和数量上存在明确的种族差异，特别是在非裔美国人和其他种族群体之间。我们提供的证据表明，冠状动脉钙作为动脉硬化的标志，在预测心脏病方面独立于炎症标志，如高敏C反应蛋白。 本研究的目的是在现已年老的SBHW队列中检查基线钙和钙化程度的七年变化对心脏功能的影响。这项研究还将研究这些老年受试者冠状动脉钙的变化与未来心脏病之间的关系。我们将通过对775名南湾心脏观察幸存者进行心脏磁共振成像(MRI)来测量收缩和舒张期功能，从而实现这些目标。这些测量被用来确定心脏是否工作正常。这项拟议的研究还将检查冠状动脉钙化评分变化之间的关系，包括那些没有进行核磁共振扫描的患者。 这项研究将在两个不同的地点分两部分进行。第一部分将在港湾-加州大学洛杉矶分校综合临床研究中心(GCRC)进行，第二部分将在洛杉矶县南加州大学(LAC USC)成像科学中心进行。在GCRC，将测量血压、心率、身高和体重。将抽取血液进行分析，并进行心电图检查。核磁共振成像将在第二部分进行，在成像科学中心进行。在安排核磁共振检查之前，将使用所有不可接受的植入物、设备和假体的清单来确定这些东西不存在于参与者的体内。所有的MRI结果和任何附带的关键发现，包括但不限于瓣膜异常、心功能不全、动脉瘤和血栓形成，将被提交给统计咨询和研究中心(SCRC)。SCRC将向与会者发送所有报告。 受试者的风险很小，主要是疼痛和瘀伤，并在MRI期间抽血和可能的幽闭恐惧症反应。幽闭恐惧症是我们为这一程序建立的排除标准之一。另一方面，受试者将从与我们的工作人员的互动中获得更多关于他们健康的意识。他们还将被告知他们的血压和脂蛋白水平，并得到适当的建议。因此，风险与收益之比正在向收益倾斜。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The South Bay Heart Watch (SBHW) study has established the presence of a definite though imperfect relationship between calcium in the heart (coronary calcium) and heart disease in asymptomatic adults at risk. We have established that this relationship is reduced in diabetic subjects and that there are definite ethnic- specific differences in the presence and amount of coronary calcium, notably between African Americans and other ethnic groups. We have provided evidence that coronary calcium, as a marker for hardening of the arteries, acts independently from markers of inflammation like high sensitivity C reactive protein in predicting heart disease. The objective of this continuation is to examine the effect of baseline calcium and seven-year change in calcium extent on the function of the heart in the now elderly SBHW cohort. This study will also examine the relation between changes in coronary calcium and future heart disease in these elderly subjects. We will accomplish these goals by performing cardiac magnetic resonance imaging (MRI) on 775 South Bay Heart Watch survivors to measure systolic and diastolic function. These measurements are used to determine if the heart is working properly. This proposed research will also examine the relation between changes in coronary calcium scores, including those without MRI scans. The study will be done in two parts, at two different sites. The first part will take place at Harbor-UCLA General Clinical Research Center (GCRC) and the second part at Los Angeles County + University of Southern California (LAC+USC) Imaging Science Center. At the GCRC, blood pressure, heart rate, height and weight will be measured. Blood will be drawn for analysis and an ECG will be done. The MRI will take place during the second part, at the Imaging Science Center. A checklist of all unacceptable implants, devices and prostheses will be used to ascertain that these things are not present in the participant's body before being scheduled for MRI. The All MRI results and any incidental critical findings including, but not limited to, valvular abnormalities, cardiac dysfunction, aneurysm and thrombosis will be forwarded to the Statistical Consultation and Research Center (SCRC). SCRC will send out all reports to the participants. Risk to the subjects is minimal, mainly pain and bruising with blood drawing and possible claustrophobic reaction during the MRI. Claustrophobia is one of the exclusion criteria we have established for this procedure. On the other hand, the subjects will gain greater awareness of their health from their interactions with our staff. They will also be informed of their blood pressures and lipoproteins levels and be given appropriate advice. Therefore the risk: benefit ratio is leaning toward benefit.