PROGRESSION CORONARY CALCIUM (SBHW)

描述：(改编自《调查者摘要》)调查者陈述 他们是在仔细考虑了 审稿人深思熟虑的评论和建议，以及广泛的修改。 具体地说，他们与斯坦利·艾岑博士的团队在 南加州大学统计数据协调中心。这个 南湾心脏观察(SBHW)是一项以人群为基础的高危对象研究 通过基线危险因素测量和冠脉钙测定 1994年进行了循证CT检查。这项研究表明，冠脉疾病与 钙与未来心血管事件的发生率。在建议的 研究人员将使用SBHW队列和NHLBI阅读中心 以及艾岑博士的数据协调中心，以检查基线风险 与钙代谢相关的因素、民族和指标 冠状动脉钙量在四到五年内的变化。他们将表演 EBCT扫描了1,000名队列中幸存的成员，并将重复执行 测量左心室肥厚、血脂、血压、 同型半胱氨酸、纤维蛋白原、甲状腺旁激素和维生素D水平。他们会 检验1994年以来风险因素之间的独立关系 基线评估和冠脉钙化积分的变化 EBCT。Logistic回归，它不依赖于正态分布 自变量，将被用来检验年化的关系 冠脉钙随事件发生率的变化。调查人员 声明这项研究将对以下方面产生重要影响 危险因素和亚临床疾病进展测量的意义 通过钙的变化，以及钙的变化与事件的关系 事件。他们还指出，关于风险影响的重要信息 亚临床疾病进展的因素和疾病向 将获得心血管事件。

DESCRIPTION: (Adapted from the Investigator's Abstract) The investigators state that they are resubmitting this application after careful consideration of the reviewers' thoughtful comments and suggestions and extensive revision. Specifically, they have joined forces with the team of Dr. Stanley Azen at the University of Southern California Statistical Data Coordinating Center. The South Bay Heart Watch (SBHW) is a population-based study of high-risk subjects with baseline risk factor measurements and coronary calcium determinations by EBCT conducted in 1994. This study has shown a modest relation between coronary calcium and the incidence of future cardiovascular events. In the proposed research, the investigators will use the SBHW cohort and NHLBI reading center as well as Dr. Azen's data coordinating center to examine whether baseline risk factors, ethnic group and indices of calcium metabolism are associated with change in coronary calcium quantity over four to five years. They will perform EBCT scans in 1,000 surviving members of the cohort and will perform repeat measurements of left ventricular hypertrophy, plasma lipids, blood pressure, homocysteine, fibrinogen, para-thyroid hormone and vitamin D levels. They will examine the independent relationships between risk factors from the 1994 baseline evaluation and the change in coronary calcium score as determined by EBCT. Logistic regression, which is not dependent on normality of the independent variables, will be used to examine the relation of annualized change in coronary calcium with the incidence of events. The investigators state that this study will have important implications regarding the significance of risk factors and progression of sub-clinical diseases measured by changes in calcium, as well as the relation of calcium change to incident events. They also state that important information regarding the effect of risk factors on sub-clinical disease progression and the transition of disease to cardiovascular events will be obtained.